Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence

Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions. Finger movement can be restored by surgery (removing the fibrosis tissue), but recurrence is a major problem and this is difficult to treat. Through microfasciectomy, the presence of small nerve bundles (micronerves) were observed. These nerves are possibly related to the hand fascia, which is the origin of Dupuytren disease. These micornerves and their dissection could play a role in the recurrence of DD. This study will investigate the role of these micronerves in DD, the impact of its dissection on formation of neuromas and on recurrence. Also, the presence of nerve growth factor (NGF) will be evaluated. The purpose is to provide information on potential neuro-induced fibrosis.

Sex

All

Minimum age

18 Years

Inclusion criteria:

Participants eligible for inclusion in this study must meet all of the following criteria:

1. The participant or his/her legally authorized representative voluntary signed the informed consent prior to the first assessment
2. Participants are ≥ 18 years and diagnosed with primary/recurrent Dupuytren disease
3. Included patients are eligible for microfasciectomy

Exclusion criteria:

Participants eligible for this study must not meet any of the following criteria:

1. Patients \< 18 years
2. Patient included in an interventional trial with an investigational medicinal product
3. Patients with cognitive impairments, severe rheumatic disease and neurological disorders leading to flexion deformities of the fingers