A Clinical Trial of TQB3454 Tablets in Healthy Adult Subjects

Inclusion Criteria:

* Sign an informed consent form before the experiment and fully understand the content, process, and potential adverse reactions of the study;
* Able to complete the study according to the requirements of the protocol;
* Subjects aged 18-65 (inclusive);
* Body mass index (BMI) ≥ 18 and ≤ 28 kg/m\^2, and male's weight ≥ 50 kg and female's weight ≥ 45 kg;
* Health status: No mental abnormalities, no history of severe neurological, respiratory, digestive, urinary, endocrine, and metabolic abnormalities;
* The subjects have no pregnancy plan, voluntarily take effective contraceptive measures, and no plans to donate sperm or eggs, from the date of signing the inform consent (14 days before signing the inform consent for female subjects) to at least 6 months after the last administration.

Exclusion Criteria:

* Subjects with allergic constitution or a history of allergies to two or more foods or drugs;
* Subjects who have experienced arterial/venous thrombosis events within 6 months, such as cerebrovascular accidents (including temporary ischemic attacks), deep vein thrombosis, and pulmonary embolism;
* Suffering from ≥ Level 2 myocardial ischemia or infarction, arrhythmia (including QTc ≥ 450 ms for male, QTc ≥ 470 ms for female), and ≥ Level 2 congestive heart failure (New York Heart Association (NYHA) classification);
* Those with multiple factors that affect oral medication (such as inability to swallow, gastrointestinal diseases);
* Have taken any prescription, over-the-counter, vitamin product, or herbal medicine within one month before the first administration;
* Take CYP3A4 inhibitors or inducers within one month before the first administration or before the study medication;
* Those who have taken a special diet (including grapefruit, etc.) or engaged in vigorous exercise within 14 days before the first administration or have other factors that affect drug absorption, distribution, metabolism, excretion, etc.;
* Abnormal and clinically significant physical examination, vital signs, electrocardiogram, and laboratory tests during the screening period;
* Donated blood or experienced significant blood loss (\>450 mL) within 3 months prior to taking the study drug;
* Participated in any clinical trial and took any investigational drug within 3 months prior to taking the study drug;
* Smoke at least 5 cigarettes per day within 3 months prior to the study;
* Positive alcohol breath test or history of alcoholism within 2 weeks prior to screening (drinking 14 units of alcohol per week: 1 unit=360 mL of beer or 45 mL of 40% alcohol or 150 mL of wine);
* Drug screening positive or those who have used drugs in the past 3 months prior to the study;
* Inability to tolerate venous puncture for blood collection or poor vascular condition;
* The subject is unable to complete the experiment due to personal reasons;
* Other conditions that it is considered not suitable for enrollment assessed by the investigators.