Clinical trial · Observational
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Network Connectivity | — | UNRESOLVED | — |
| Dexmedetomidine | — | UNRESOLVED | — |
| Postoperative Delirium | — | UNRESOLVED | — |
| Propofol | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Propofol | Drug | — | UNRESOLVED |
| Remimazolam Injection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Dex group
- description
- Participants will be sedated and maintained by dexmedetomidine.
- interventionNames
- Drug: Dexmedetomidine
- label
- Propofol group
- description
- Participants will be sedated and maintained by propofol.
- interventionNames
- Drug: Propofol
- label
- Remimazolam group
- description
- Participants will be sedated and maintained by remimazolam.
- interventionNames
- Drug: Remimazolam Injection
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed as unilateral supratentorial glioma by MRI * Selective operation * Age over 18 years old * ASA I-II * Right handedness Exclusion Criteria: * History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs * History of intracranial surgery * Drug and/or alcohol abuse * History of dementia or mental illness * Pregnant or lactating women * Contraindications for MRI * Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block * Severe hepatic or renal dysfunction
References
Publications (0)
Data not yet available