Clinical trial · Observational
Profiles of Expression in HPV+ Versus HPV Head and Neck Cancers
Assessment of Genomic Alterations and Profiles of Expression in HPV+ Versus HPV Head and Neck Cancers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Feasibility issue
Summary
Brief summary (as posted)
Squamous cell cancers of the head and neck are classically correlated to excessive consumption of alcohol and tobacco and have a rather poor prognosis. However, the incidence of Head and Neck cancers in patients without alcohol-smoking risk factor has continued to increase in recent years, in relation to more and more frequent HPV contamination. Some studies show a difference in the expression of certain genes within the two groups of tumors (HPV+ and HPV-) including some that confer sensitivity to certain chemotherapies and others to radiotherapy. However, patients with HPV+ Head and Neck cancers are treated according to the same referential as HPV- Head and Neck cancers. There is therefore a real need for studies identifying predictive markers in order to be able to offer patients a more effective suitable and less invasive treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PCR - Immunohistochemistry - Immunolabelling | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- HPV + Group
- description
- Patients with positive HPV diagnosis
- interventionNames
- Genetic: PCR - Immunohistochemistry - Immunolabelling
- label
- HPV - Group
- description
- Patients with negative HPV diagnosis
- interventionNames
- Genetic: PCR - Immunohistochemistry - Immunolabelling
Primary outcomes (1)
- measure
- Molecular profile of oropharyngeal or oral cavity HPV positive and negative tumors
- timeFrame
- 1 day
- description
- Molecular profile of tumors will be established with analysis of 87 "Hotspot" genes, full length analysis of 48 genes, copy number analysis of 43 genes and gene fusion (inter and intra genic) of 51 genes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with oropharyngeal squamous cell carcinoma or the oral cavity histologically proven. * Primary tumor for which a biopsy or excision is required available and sufficient to carry out molecular analysis Exclusion Criteria: \- Patient with Head and Neck cancer other than oropharyngeal or oral cavity squamous cells carcinomas
References
Publications (0)
Data not yet available