Clinical trial · Observational
Spatial Location of Breast Cancer Local Recurrence After Mastectomy
Spatial Location of Breast Cancer Local Recurrence After Mastectomy: the Secret Study, a Retrospective Analysis.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rationale:To improve the definition of the target volume for radiotherapy of the chestwall after different types of mastectomy, the exact localization of regions at risk for a local recurrence should be known. However, there are currently insufficient data in literature showing where local recurrences occur after different types of mastectomy. Objective: The primary objective of the proposed study is to determine whether the spatial, location of a breast cancer recurrence after mastectomy, differs for different types of mastectomy. Study design: Retrospective study evaluating spatial location and site of recurrences after mastectomy. Study population: The investigators aim to include all breast cancer patients treated with mastectomy in the Netherlands between 2003- 2008, and known to have experienced a local recurrence as the first site of failure. Primary endpoint: Spatial location of local recurrence (e.g., primary tumour bed, scar, skin, subcutaneous, nipple, areola, pectoral muscles).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mastectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Spatial localisation of local recurrences
- timeFrame
- Up to 15 years after mastectomy
- description
- The primary objective of the proposed study is to determine whether the spatial, location of a breast cancer recurrence after mastectomy, differs for different types of mastectomy.
Secondary outcomes (2)
- measure
- Influence of tumour characteristics on the site of recurrence and spatial location.
- timeFrame
- Up to 15 years after mastectomy
- description
- Anaysis to assess whether tumour characteristics (e.g., molecular subtypes, lymphangio/lymphovascular invasion) influence the site of recurrence and spatial location.
- measure
- Influence of treatment-related factors on the site of recurrence and spatial location.
- timeFrame
- Up to 15 years after mastectomy
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years and more at the time of breast cancer diagnosis. * Proven histology of first invasive breast cancer * Mastectomy as a surgical procedure for breast cancer (regardless of perioperative treatment). * Having a local recurrence, as primary event * reast cancer diagnosis in the period 2003-2008. Exclusion Criteria: * Non-epithelial histology. * Primary metastatic breast cancer. * Mastectomy for breast cancer recurrence after earlier breast conserving therapy. * Synchronous breast cancer.
References
Publications (0)
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