Clinical trial · Observational
Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study Aim is creation of the Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF) for a comprehensive assessment of the influence of gender characteristics, clinical and anamnestic factors, body composition, topical characteristics of congestion, instrumental data and markers of cellular inflammation and stress on immediate and long-term outcomes in patients with acute decompensated heart failure with preserved ejection fraction. During the study it is planned to assess gender, clinical and anamnestic indicators preceding hospitalization of patients in the hospital; characterize the features of comorbid status in the studied group of patient; study the features of drug therapy at the prehospital stage and during hospitalization in the study group of patient; assess adverse hospital outcomes and outcomes 6 months after hospital discharge and identify factors associated with them; assess body composition in patients with acute decompensated heart failure with preserved ejection fraction in obese patients upon admission to the hospital; characterize the severity and topical characteristics of congestion and compare with the phenotypes of acute decompensation of heart failure; asess adverse in-hospital outcomes and outcomes 6 months after hospital discharge and identify factors associated with them; conduct a clinical and instrumental examination of patients diagnosed with compensated and decompensated HFpEF, verified by echocardiography at rest, as well as in patients with HFpEF verified after an additional diastolic stress test with assessment of intracardiac hemodynamic; analyze the serum concentrations of biochemical markers associated with cellular stress in these groups of patients, as well as in the control group of apparently healthy people; conduct an analysis of associations of biomarker levels with clinical characteristics of patients, the presence of comorbid diseases, including obesity, as well as with data from instrumental examination methods; assess the diagnostic capabilities of HFpEF, defined by various criteria, based on the concentration of the new biomarkers The results obtained will allow us to evaluate the characteristics of the course and outcomes of the disease in Moscow patients, depending on the phenotype of acute decompensation of HFpEF, hospitalized in the hospital during the study period. It is expected to identify phenotypes of acute decompensation of HFpEF that affect the duration of hospitalization and the development of adverse outcomes in the hospital and long-term period of the disease.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Decompensated Heart Failure | — | UNRESOLVED | — |
| Heart Failure With Preserved Ejection Fraction | — | UNRESOLVED | — |
| Obesity, Mild | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bioimpedance | Diagnostic Test | — | UNRESOLVED |
| Echocardiography | Diagnostic Test | — | UNRESOLVED |
| Immunoassay | Diagnostic Test | — | UNRESOLVED |
| Routine biochemistry | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patient with HFpEF with decompensation
- description
- 120 patients hospitalized with a clinical picture of acute decompensation of heart failure (shortness of breath, orthopnea, clinical signs of "cardiac asthma" and/or "pulmonary edema") in the city clinical hospital named after. V.V. Veresaeva, Moscow. Patients with a confirmed diagnosis in accordance with instrumental and/or laboratory criteria
- interventionNames
- Diagnostic Test: Echocardiography
- Diagnostic Test: Bioimpedance
- Diagnostic Test: Immunoassay
- Diagnostic Test: Routine biochemistry
- label
- Control group
- description
- 40 particularly healthy people without heart failure and acute cardiovascular diseases
- interventionNames
- Diagnostic Test: Bioimpedance
- Diagnostic Test: Immunoassay
- Diagnostic Test: Routine biochemistry
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: All patients hospitalized with a clinical picture of acute decompensation of heart failure (shortness of breath, orthopnea, clinical signs of "cardiac asthma" and/or "pulmonary edema") in the city clinical hospital named after. V.V. Veresaeva, Moscow. Patients with a confirmed diagnosis in accordance with instrumental (EchoCG) and/or laboratory criteria. Exclusion Criteria: Refusal to sign informed consent to participate in a clinical trial and to process personal data.
References
Publications (5)
- BACKGROUNDTimofeev YS, Kiselev AR, Dzhioeva ON, Drapkina OM. Heat Shock Proteins (HSPs) and Cardiovascular Complications of Obesity: Searching for Potential Biomarkers. Curr Issues Mol Biol. 2023 Nov 23;45(12):9378-9389. doi: 10.3390/cimb45120588. PMID 38132434
- RESULTRogozhkina E.A., Vedenikin T.Yu., Timofeev Yu.S., Ivanova A.A., Afaunova A.R., Dzhioeva O.N., Drapkina O.M. Comparative assessment of venous congestion severity and hospitalization outcomes in patients with acute decompensated heart failure with preserved ejection fraction. Russian Journal of Cardiology. 2024;29(7):5977. (In Russ.) https://doi.org/10.15829/1560-4071-2024-5977. EDN: RGBFNE
- RESULTTimofeev Yu.S., Afaunova A.R., Ivanova A.A., Vedenikin T.Yu., Dzhioeva O.N., Metelskaya V.A., Pokrovskaya M.S., Drapkina O.M. Interaction of serum heat shock proteins' levels with the severity of venous congestion in patients with acute decompensated heart failure with preserved ejection fraction. Cardiovascular Therapy and Prevention. 2024;23(6):4037. (In Russ.) https://doi.org/10.15829/1728-8800-2024-4037. EDN: HXKJTD
- RESULTTimofeev Yu.S., Vedenikin T.Yu., Afaunova A.R., Zamyatin R.A., Metelskaya V.A., Dzhioeva O.N., Ivanova A.A., Neshkova E.A., Pokrovskaya M.S., Drapkina O.M. Heat shock proteins in the assessment of the course and prognosis of heart failure with preserved ejection fraction. Russian Journal of Cardiology. 2025;30(4):6317. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6317. EDN: YHFXWZ
- RESULTTimofeev Yu.S., Metelskaya V.A., Ivanova A.A., Dubovskaya N.I., Rogozhkina E.A., Vedenikin T.Yu., Zamyatin R.A., Borisova A.L., Dzhioeva O.N., Drapkina O.M. Serum biochemical profile in patients with decompensated heart failure with preserved ejection fraction depending on obesity. Cardiovascular Therapy and Prevention. 2025;24(7):4453. (In Russ.) https://doi.org/10.15829/1728-8800-2025-4453. EDN: TEWGYU