Clinical trial · Observational
Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer
The Ambidirectional Cohort Study of Neurovascular Complications After Radiation Therapy in Head and Neck Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity. Radiotherapy is usually the standard treatment of Head and neck cancers. In the present study, investigators aim to study the prevalence of cervical-cranial vascular complications during the early stages in these Head and neck cancer patients receiving Radiotherapy. Investigators will also compare the results between Nasopharyngeal cancer and other Head and neck cancerpatients receiving Radiotherapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neurovascular Complications | — | UNRESOLVED | — |
| Radiation Treatment | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (9)
- measure
- Significant CAS at internal carotid artery or common carotid artery
- timeFrame
- 1 year
- description
- We define significant CAS as (a) \>50% stenosis on the B-mode with peak systolic velocities ≥120 cm/s based on the hemodynamic criteria at any internal carotid artery or common carotid artery in the CDU study according to the standard ultrasound criteria35; or (b) \> 50% diameter stenosis on the follow up CT or MR images.
- measure
- Cerebral infarctions (CI)
- timeFrame
- 1 year
- description
- The CI is defined whenever there were symptomatic IS occurrence of presence of asymptomatic IS on the reviewed brain MRIs.
- measure
- Significant extracranial vertebral artery stenosis (VAS)
- timeFrame
- 1 year
- description
- \> 50% diameter stenosis on the follow up CT or MR images.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Population: Prospective cohort Inclusion Criteria: 1. Age ≥20 years. 2. Head and neck cancer patient . 3. Had ever received radiation therapy (RT) ≦ 72 months before inclusion in the registry. 4. Had ≥ 1 brain images and cervical-cranial vascular studies between the end of RT and d date of enrolment. Exclusion Criteria: 1. Age \<20 years. 2. Patients not willing to sign the informed consent. Population: Retrospective validation cohort Inclusion Criteria: 1. Age ≥20 years. 2. Head and neck cancer patient. 3. Had ever received radiation therapy (RT) \> 120 months before the adoption date of IRB at the participant site. 4. Had ≥ 2 brain images and cervical-cranial vascular studies between the end of RT and 6\~10 years after RT, one within 5 years after RT, the other after 5 years after RT. Exclusion Criteria: 1.Age \<20 years.
References
Publications (1)
- DERIVEDJiang JL, Chang JT, Huang BS, Chang TY, Sung PS, Wei YC, Lin CY, Yeh CH, Fan KH, Liu CH. Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer. BMC Cancer. 2025 Feb 11;25(1):235. doi: 10.1186/s12885-025-13647-6. PMID 39934712