Bladder Bank (a Prospective Banking Study)

Inclusion Criteria:

* Age \> 18 years
* Patient has undergone office-based evaluation for hematuria \[computed tomography (CT), ultrasound, cystoscopy\]

Exclusion Criteria:

* Patient has known cancer outside of the target cancer 5 years prior to current collection (not including basal cell or squamous cell skin cancers; if patient has not been seen or if information is not available, the patient is eligible)
* Patient has recurrent muscle invasive bladder cancer
* Patient has ever been previously diagnosed with UTUC (upper tract urothelial carcinoma) prior to bladder resection
* Patient has received chemotherapy class drugs for the treatment of non-target origin cancer in the 5 years prior to current collection
* Patient has had any prior radiation therapy to the target lesion prior to current collection
* Patient has had a biopsy to the target organ and/or lesion within 3 days before collection
* Patient has undergone cystectomy or cystoprostatectomy
* Patient has transurethral instrumentation (placement of urinary catheter) within 7 days prior to urine collection
* Patient has had a urinary tract infection within 14 days prior to urine collection
* Patient has chronic indwelling urinary catheter