Clinical trial · Interventional
Binaural Sound for Remimazolam Induction
The Effect of Preoperative Binaural Sound on Remimazolam Dose Required for Induction of General Anesthesia: a Randomized, Placebo-controlled Trial
NCT06099977CI-TRIAL-00071485unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is important to decrease the time-to-loss of consciousness and anesthetics dose of remimazolam for general anesthesia induction. We will evaluate the effect of binaural sound for general anestheia induction using remimazolam infusion.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| General Anesthesia | — | UNRESOLVED | — |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Uterine Myoma | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Binaural sound | Procedure | — | UNRESOLVED |
| Placebo | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- I (Binaural)
- description
- Binaural sound using headphone will be applied.
- interventionNames
- Procedure: Binaural sound
- type
- PLACEBO_COMPARATOR
- label
- II (Placebo)
- description
- Only headphone without sound will be applied.
- interventionNames
- Procedure: Placebo
Primary outcomes (1)
- measure
- Remimazolam dose for no response to voice
- timeFrame
- At anesthesia day 0
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients scheduled for generla anesthesia 2. Patients aged 20-60 3. Patients with American Society of Anesthesiologist physical status classification 1-2 4. Patients with ideal body weight 50-80 kg Exclusion Criteria: 1. Patients with hearing disability 2. Patients using opioids or sedatives in 1 week 3. Patients who are dependent for alcoholics or drugs 4. Patients with hypersensitivities to remimazolam 5. Patients with arrhythmia, cardiovascular disease, heart failure, or hypovolemia 6. Patients with liver failure
References
Publications (1)
- DERIVEDKim HC, Sohn JY, Kim MH, Kim YJ, Chang CH, Seo JH. Preoperative binaural beats reduce remimazolam dosage and enhance safety in anesthesia induction: A randomized controlled trial. PLoS One. 2026 Mar 30;21(3):e0345960. doi: 10.1371/journal.pone.0345960. eCollection 2026. PMID 41911215