Clinical trial · Interventional
ASCENT Intervention for Brain Tumor Patients
An ACT-Based Supportive Intervention for Patients With Central Nervous System Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to refine and test a psychosocial intervention called ASCENT (ACT-based Supportive intervention for patients with CENTral nervous system tumors). This intervention was developed to help patients after being diagnosed with a brain tumor. The main question this study aims to answer is whether this intervention is feasible (i.e., possible to carry out) and acceptable (i.e., considered helpful) to patients. Participants will be asked to take part in 6 coaching sessions and complete short surveys at four different time points. Some participants will be asked to share feedback via interviews.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Coping Skills | — | UNRESOLVED | — |
| Distress, Emotional | — | UNRESOLVED | — |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
| Malignant Brain Tumor | Malignant Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Psychosocial intervention | Behavioral | — | UNRESOLVED |
| Usual supportive care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Pilot RCT: ASCENT Arm
- description
- Enrolled patients will receive an intervention manual and will participate in six weekly or biweekly individual sessions with a clinician (e.g. nurse or behavioral health specialist). Participants will be asked to complete surveys at baseline, 6 weeks, 12 weeks, and 16 weeks.
- interventionNames
- Behavioral: Psychosocial intervention
- type
- ACTIVE_COMPARATOR
- label
- Pilot RCT: Control Arm
- description
- Participants will receive usual supportive care, which includes referral to cancer center supportive care services (e.g., social work) upon request from the patient, caregiver, or clinician. Participants will be asked to complete surveys at baseline, 6 weeks, 12 weeks, and 16 weeks.
- interventionNames
- Other: Usual supportive care
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 * Massachusetts General Hospital Cancer Center Patient * Within 6 months of diagnosis of malignant primary Central Nervous System (CNS) tumor * English speaking Exclusion Criteria: * Inability to provide informed consent as assessed by the study team (e.g., due to severe cognitive impairment/dementia) * Moderate to severe receptive aphasia (Quick Aphasia Battery sentence comprehension subscale \< 8) * Current or imminent hospice enrollment
References
Publications (0)
Data not yet available