Clinical trial · Observational
Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Association of Serum and Salivary Dipeptidyl Peptidase-4 (DPP-4) With Oral Cancerous and Precancerous Lesions; an Observational Diagnostic Accuracy Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim: The current study targets linking serum and salivary dipeptidyl peptidase-4 with oral squamous cell carcinoma and comparing it with potentially malignant lesions and control to validate dipeptidyl peptidase-4 as a diagnostic marker for early detection of oral cancer and to reveal its possible role in carcinogenesis. Methodology: A total of 45 patients were recruited and subdivided into 2 groups: Group I: 15 patients having oral squamous cell carcinoma. Group II: 15 patients with potentially malignant lesions (leukoplakia and oral lichen planus) compared to 15 systemically healthy participants having no oral mucosal lesions acting as a control group (Group III). Serum and whole unstimulated salivary samples were collected from all participants to evaluate dipeptidyl peptidase level in different groups using enzyme linked immune-sorbent assay (ELISA) kit. ROC analysis was done to reveal area under the curve, sensitivity, specificity and diagnostic accuracy of DPP-4 among different groups.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
| Oral Premalignant Lesions as Leukoplakia and Lichen Planus | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| serum and unstimulated salivary samples | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Group I
- description
- patients suffering from oral squamous cell carcinoma
- interventionNames
- Diagnostic Test: serum and unstimulated salivary samples
- label
- Group II
- description
- patients diagnosed with potentially malignant lesions such as leukoplakia, and dysplastic erosive or atrophic oral lichen planus
- interventionNames
- Diagnostic Test: serum and unstimulated salivary samples
- label
- Group III
- description
- individuals with no oral mucosal lesions
- interventionNames
- Diagnostic Test: serum and unstimulated salivary samples
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * systemically healthy * No current medication, * both genders with age ranging from 30 to 65 years old. * having oral leukoplakia, oral lichen planus or oral squamous cell carcinoma Exclusion Criteria: * systemic disease * pregnancy * lactation * being diagnosed with any other oral mucosal lesion
References
Publications (1)
- DERIVEDAbdel Fattah Tarrad N, Gamil Shaker O, Abdelkawy M, Hassan S. Association of serum and salivary dipeptidyl peptidase-4 (DPP-4) with oral cancerous and precancerous lesions; an observational diagnostic accuracy study. BMC Oral Health. 2024 Oct 10;24(1):1206. doi: 10.1186/s12903-024-04939-7. PMID 39390508