Clinical trial · Interventional
Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal Tumors
Observation and Intervention Study of Brain-Gut Function Reconstruction After Intersphincteric Resection (ISR) for Ultra-Low Rectal Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate the effects of intersphincteric resection (ISR) of ultra-low rectal tumor on the brain-rectoanal function of patients, and to precisely localize the cerebral functional regulatory regions for intervention targets of anorectal remodeling. Utilizing transcranial magnetic stimulation(TMS) technology to explore the functional remodeling of the "new" anorectal muscle groups and provide a theoretical basis for more research on the rehabilitation and mechanism of fecal incontinence.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Neoplasms | Rectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sham Transcranial magnetic stimulationt | Device | — | UNRESOLVED |
| Transcranial magnetic stimulation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- SHAM_COMPARATOR
- label
- Sham Stimultion Group
- description
- Patients on the Sham stimulation group will be interfered with the stimulation coil perpendicular to the skull, so that they will hear the sound of machine without having therapeutic effects. The parameters will be the same as those in the stimulation group.
- interventionNames
- Device: Sham Transcranial magnetic stimulationt
- type
- ACTIVE_COMPARATOR
- label
- Pre-ileostomy-closure Stimultion Group
- description
- Patients on the Pre-ileostomy-closure group will be interfered with stimulation 3 weeks before the procedure of ileostomy closure.
- interventionNames
- Device: Transcranial magnetic stimulation
- type
- ACTIVE_COMPARATOR
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Primary ultra-low rectal tumor patient who is received intersphincteric resection and preventive ileostomy was performed. * Patient who is willing to participate in the study, and voluntarily sign informed consent. Exclusion Criteria: * Anastomotic leakage or other serious complications occur after surgery. * Advanced tumor, tumor recurrence or metastasis. * Patients with contraindications of fMRI scanning, such as history of metal implants in the body, claustrophobia, etc. * Patients with contraindications for TMS treatment, such as intracranial metal implants, epilepsy history, heart disease with unstable heart function, retinal detachment, etc. * Combined with organic brain disease and drug abuse history. * Combined with other mental diseases. * Pregnant or lactating women.
References
Publications (0)
Data not yet available