Clinical trial · Interventional
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
Assessment of Laryngopharyngeal Sensation in Patients With Laryngopharyngeal Disorders
NCT06078527CI-TRIAL-00092482not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 19, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260919-000001
Summary
Brief summary (as posted)
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders. This study will expand on the previous research to include a separate cohort of adults being seen in clinic for an existing laryngopharyngeal disorder resulting from previous radiation or other cancer treatments.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aspiration | — | UNRESOLVED | — |
| Globus Pharyngeus | — | UNRESOLVED | — |
| Iatrogenic Injury | — | UNRESOLVED | — |
| Laryngeal Disease | — | UNRESOLVED | — |
| Larynx Paralysis | — | UNRESOLVED | — |
| Presbylarynx | — | UNRESOLVED | — |
| Sensory Neuropathy | — | UNRESOLVED | — |
| Spasmodic Dysphonia | — | UNRESOLVED | — |
| Vocal Cord Paralysis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cheung-Bearelly Aesthesiometer | Device | — | UNRESOLVED |
| Questionnaires | Other | — | UNRESOLVED |
| Transnasal Laryngoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cancer Survivors
- description
- Participants will attend a single 15-30 minute study session during which they will answer questionnaires (5-10 minutes) and undergo laryngopharyngeal sensory testing (10-20 minutes). There will be up to 2 years of medical record follow up after completing the main study.
- interventionNames
- Device: Cheung-Bearelly Aesthesiometer
- Procedure: Transnasal Laryngoscopy
- Other: Questionnaires
Primary outcomes (2)
- measure
- Percentage of participants with triggered/positive laryngeal adduction response (LAR)
- timeFrame
- 1 day
- description
- Elicitation of LAR is defined as a unilateral or bilateral laryngeal adduction immediately following laryngeal stimulus through frame-by-frame analysis of video recordings (visualized on laryngoscopy). An acceptable tactile stimulus is near orthogonal (less than 30 degrees deviation) to the mucosal surface and unobstructed by salivary forces. The percentage of participants with LAR will be reported
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age \<=18 years. 2. Individuals without a laryngopharyngeal disorder (health controls) or with a laryngopharyngeal disorder. Laryngopharyngeal disorder includes but is not limited to: presbylarynx, aspiration; spasmodic dysphonia; globus pharynges; vocal fold paralysis; iatrogenic injury to the larynx; muscle tension dysphonia; neurogenic dysphagia; laryngeal sensory neuropathy; and laryngopharyngeal disorders resulting from prior radiation therapy in individuals with a history of head and neck cancer who have completed radiation therapy as primary or adjuvant cancer treatment 3. Ability and willingness to comply with study procedures. 4. Ability to understand a written informed consent document, and the willingness to sign it. Exclusion Criteria: 1. Non-English speaking. 2. Laryngopharyngeal structures are not accessible on exam. 3. Known contraindication to any study-related procedure, or history of being unable to tolerate laryngoscopy. 4. Vocal fold immobility or severe hypomobility on adduction. 5. For head and neck cancer survivors only: Currently undergoing radiation therapy for head and neck cancer (i.e., primary/adjuvant radiation therapy treatment plan is not yet completed).
References
Publications (0)
Data not yet available
No reference posted for this study.