DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies

DANISH.MRD part I - Surgery

Inclusion Criteria:

* Colon or rectal cancer, clinical tumor stage I-III.
* Patient able to understand and sign written informed consent.
* Scheduled for curative-intent resectional surgery (including "compromised" curative resections).

Exclusion Criteria:

* Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome.
* Inflammatory bowel disease (Crohn's disease or ulcerative colitis).
* Verified distant metastases.
* Malignant colorectal polyps diagnosed after polypectomy.
* Patients who are unlikely to comply with the protocol (e.g., uncooperative attitude, inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study.

DANISH.MRD part II - Surveillance

Inclusion Criteria:

* Participation in DANISH.MRD part I - Surgery.
* Colorectal cancer, UICC stage III.
* Has received curative-intent resection and is a candidate for adjuvant chemotherapy (3- or 6-months regime).

Exclusion Criteria:

* Not treated with adjuvant chemotherapy
* Treated with neoadjuvant chemo-radiation therapy.
* Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma).
* Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening.
* Patients who are unlikely to comply with the protocol (e.g., uncooperative attitude, inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study.