Clinical trial · Observational
An Organoid-based Functional Precision Medicine Trial in Osteosarcoma
An Organoid-based Functional Precision Medicine Trial in Osteosarcoma: PREMOST
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to examine if we can predict sensitivity of osteosarcoma to different chemotherapy agents using tissue cultures in the laboratory. We know that different chemotherapy agents can be used in the treatment, but not every sarcoma responds to them equally. It is important to understand if testing of the tissue obtained during a routine biopsy or surgery may be useful in selecting appropriate treatments. In addition, additional testing of the tumor, including genetic testing, will help us to understand osteosarcoma better.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteosarcoma | Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| standard of care biopsy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Group 1: local tumor
- description
- patients with localized osteosarcoma who are scheduled to undergo diagnostic biopsy and are planned for surgical excision of the primary tumor
- interventionNames
- Other: standard of care biopsy
- label
- Group 2: metastatic disease
- description
- patients with metastatic osteosarcoma who are scheduled to undergo either biopsy or surgery of metastatic disease
- interventionNames
- Other: standard of care biopsy
Primary outcomes (1)
- measure
- organoids from initial biopsy
- timeFrame
- two years
- description
- To assess the feasibility of establishing organoids from initial biopsy and from postsurgical sample in patients with osteosarcoma, both in patients with localized disease and metastatic disease
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion / exclusion criteria - Group1: \- Patients without diagnosis of osteosarcoma and whose imaging studies are suggestive of osteosarcoma and who are planned to undergo biopsy or surgery for diagnostic purposes Inclusion / exclusion criteria - Group 2: \- Patients whose imaging studies are suggestive of metastatic osteosarcoma and who are planned to undergo biopsy or surgery for diagnostic purposes
References
Publications (0)
Data not yet available