Clinical trial · Observational
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Effects of Perioperative Circulating Adiponectin Levels on Postoperative Systemic Inflammatory Response in Patients Undergoing Major Colorectal Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic infflammmatory response syndrome (SIRS). Dysregulated and overrated SIRS in early postoperative period can lead to complications with additional comorbidities, longer hospital stay and poorer outcome. A low grade chronic infflammatory state in obesity and hypoadiponectinemia can enable the cytokine storm and exaggerated /dysregulated SIRS in obese patients after surgery. Obesity according to this knowledge presents independent risk factor for developing more severe systemic infflamatory response syndrome in early postoperative period after major abdominal surgery. Also, chronic intestinal and gut infflamation is leading theory in oncogenesis of colorectal carcinoma according to recent findings. Many studies find low adiponectin levels in patients with colorectal carcinoma compared to healthy population. Obesity and colorectal cancer have infflamation and low adiponectin level as mutual factor which can be the important key in pathophysiology process of colorectal oncogenesis which are extremly complicated , multifactorial and intertwining. Hypothesis: Lower blood adiponectin levels are associated with higher systemic infflamatory response in patients after major abdominal surgery. Major aim of this study is to investigate correlation between perioperative blood levels of adiponectin and clinical signs of systemic infflamation and blood markers of systemic infflamation in patients after major colorectal surgery.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adiponectin | — | UNRESOLVED | — |
| Colorectal Carcinoma (CRC) | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.85 |
| Obesity, Abdominal | — | UNRESOLVED | — |
| Postoperative Complications | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
| Systemic Inflammatory Response Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| IL-6 | Diagnostic Test | — | UNRESOLVED |
| Postoperative complications | Other | — | UNRESOLVED |
| Postoperative systemic infflamation | Other | — | UNRESOLVED |
| serum levels of adiponectin | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- all patients presenting for elective open colorectal resection due to colorectal carcinoma
- interventionNames
- Diagnostic Test: serum levels of adiponectin
- Diagnostic Test: IL-6
- Other: Postoperative systemic infflamation
- Other: Postoperative complications
Primary outcomes (1)
- measure
- Adiponectin
- timeFrame
- Preoperative, 24 hours after surgery, 72 hours after surgery
- description
- Three measurements of adiponectin will be taken from blood samples of every patient preoperative, 24 and 72 hours postoperative
Secondary outcomes (1)
- measure
- IL-6
- timeFrame
- Preoperative, 24 hours after surgery, 72 hours after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Diagnose of colorectal cancer Age \>18 years Patient presenting for major (open) elective colorectal surgery according to carcinoma. Written informed consent. Exclusion Criteria: Age\<18 years BMI\<18.5kg/m2 Acute surgical conditions Established acute systemic/local infection Chronic/actual corticosteroid therapy Active immunomodulation therapy Allergie to used anestehetics/analgetics in study. Patient refusal Laparoscopic surgery Massive intraoperative surgical bleeding Preexisting concomitant second carcinoma other than colorectal origin Patients which does not fulfill inclusion criteria
References
Publications (5)
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- BACKGROUNDBoersema GSA, Wu Z, Menon AG, Kleinrensink GJ, Jeekel J, Lange JF. Systemic Inflammatory Cytokines Predict the Infectious Complications but Not Prolonged Postoperative Ileus after Colorectal Surgery. Mediators Inflamm. 2018 Mar 6;2018:7141342. doi: 10.1155/2018/7141342. eCollection 2018. PMID 29692682
- BACKGROUNDBarbic J, Ivic D, Alkhamis T, Drenjancevic D, Ivic J, Harsanji-Drenjancevic I, Turina I, Vcev A. Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C- reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? Coll Antropol. 2013 Mar;37(1):195-201. PMID 23697273
- BACKGROUNDNeskovic N, Mandic D, Marczi S, Skiljic S, Kristek G, Vinkovic H, Mraovic B, Debeljak Z, Kvolik S. Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients. Front Pharmacol. 2021 Apr 15;12:656748. doi: 10.3389/fphar.2021.656748. eCollection 2021. PMID 33935773
- BACKGROUNDWei Y, Zhu F, Gong J, Yang J, Zhang T, Gu L, Zhu W, Guo Z, Li Y, Li N, Li J. High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease. Gastroenterol Res Pract. 2018 Apr 3;2018:6270514. doi: 10.1155/2018/6270514. eCollection 2018. PMID 29849595