Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients

Inclusion Criteria:

* Patients ≥ 18 years old

  * Malnourished patients according to GLIM criteria
  * Patients with a high energy requirement (1.5kcal/ml) requiring the intake of 2 bottles of ONS per day for at least 12 weeks
  * Patients presenting any of the following clinical situations:
* Elderly patients requiring oral nutritional support
* Patients with digestive pathology including but not restricted to inflammatory bowel disease, short bowel syndrome, pancreatitis, without active malabsorption and maldigestion.
* Chronic diseases such as COPD, mild to moderate renal disease, HIV
* Oncologic patients with Eastern Cooperative Oncology Group (ECOG) 0-1

  * Patients who have given their consent to participate
  * Patients who, in the opinion of the physician, have the capacity to answer the study questionnaires themselves or their caregivers

Exclusion Criteria:

* Patients who need ONS due to surgical or acute illness\*

  * Patients with known intolerance or allergy to cow's milk, soya or peas
  * Patients with hyperthyroidism. Patients with uncontrolled hypothyroidism
  * Uncontrolled diabetic patients (HbA1c \>8%)
  * Patients requiring enteral nutrition by tube or ostomy
  * Patients with moderate and serious renal insufficiency \< 30ml/min/1,73 m2
  * Patients who have value creatinine:

    * 1,70 mg/dl - 150,31umol/L Men
    * 1,50 mg/dl - 132,63umol/L Women
  * Patients with levels of haemoglobin \<10 g/dl, transferrin \<150 mg /dl