Clinical trial · Interventional
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy In Right Cancer Colon Patients: A Randomized Controlled Trial
NCT06049758CI-TRIAL-00069865not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission, anastomotic leakage, lymph node harvesting in the final specimen, and six months follow up and overall survival time after 5-years
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leakage | — | UNRESOLVED | — |
| Blood Loss | — | UNRESOLVED | — |
| Blood Transfusion | — | UNRESOLVED | — |
| Intensive Care | — | UNRESOLVED | — |
| Lymph Node Disease | — | UNRESOLVED | — |
| Survival | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enoxaparin 40 Mg/0.4 mL Injectable Solution | Drug | — | UNRESOLVED |
| LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (Conventional) | Procedure | — | UNRESOLVED |
| LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention) | Procedure | — | UNRESOLVED |
| Levofloxacin 500mg | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Laparoscopic hemicolectomy with Complete Mesocolic Excision
- description
- Patients will have laparoscopic hemicolectomy with Complete Mesocolic Excision, D3 lymph node dissection.
- interventionNames
- Procedure: LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention)
- Drug: Enoxaparin 40 Mg/0.4 mL Injectable Solution
- Drug: Levofloxacin 500mg
- type
- ACTIVE_COMPARATOR
- label
- Conventional laparoscopic right hemicolectomy
- description
- Patients will have conventional laparoscopic right hemicolectomy with D2 lymph node dissection.
- interventionNames
- Drug: Enoxaparin 40 Mg/0.4 mL Injectable Solution
- Drug: Levofloxacin 500mg
- Procedure: LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (Conventional)
Primary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with right-side colon cancer (caecum, ascending, or hepatic flexure) * Diagnosed by CT entero-colonography * Diagnosed by colonoscopy * Diagnosed by biopsy. Exclusion Criteria: * Emergency surgery (obstruction, perforation with generalized peritonitis), * Metastatic tumor diagnosed * ASA score of IV or higher * Need for more than one surgical procedure * Conversion to open surgery
References
Publications (11)
- BACKGROUNDColon Cancer Laparoscopic or Open Resection Study Group; Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, Haglind E, Pahlman L, Cuesta MA, Msika S, Morino M, Lacy A, Bonjer HJ. Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol. 2009 Jan;10(1):44-52. doi: 10.1016/S1470-2045(08)70310-3. Epub 2008 Dec 13. PMID 19071061
- BACKGROUNDPigazzi A, Hellan M, Ewing DR, Paz BI, Ballantyne GH. Laparoscopic medial-to-lateral colon dissection: how and why. J Gastrointest Surg. 2007 Jun;11(6):778-82. doi: 10.1007/s11605-007-0120-4. PMID 17562120
- BACKGROUNDAdamina M, Manwaring ML, Park KJ, Delaney CP. Laparoscopic complete mesocolic excision for right colon cancer. Surg Endosc. 2012 Oct;26(10):2976-80. doi: 10.1007/s00464-012-2294-4. Epub 2012 May 2. PMID 22549374
- BACKGROUNDBenz S, Tam Y, Tannapfel A, Stricker I. The uncinate process first approach: a novel technique for laparoscopic right hemicolectomy with complete mesocolic excision. Surg Endosc. 2016 May;30(5):1930-7. doi: 10.1007/s00464-015-4417-1. Epub 2015 Jul 21. PMID 26194254
- BACKGROUNDWatanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H, Ishiguro M, Kanemitsu Y, Kokudo N, Muro K, Ochiai A, Oguchi M, Ohkura Y, Saito Y, Sakai Y, Ueno H, Yoshino T, Fujimori T, Koinuma N, Morita T, Nishimura G, Sakata Y, Takahashi K, Takiuchi H, Tsuruta O, Yamaguchi T, Yoshida M, Yamaguchi N, Kotake K, Sugihara K; Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012 Feb;17(1):1-29. doi: 10.1007/s10147-011-0315-2. Epub 2011 Oct 15. PMID 22002491
- BACKGROUNDKobayashi H, West NP, Takahashi K, Perrakis A, Weber K, Hohenberger W, Quirke P, Sugihara K. Quality of surgery for stage III colon cancer: comparison between England, Germany, and Japan. Ann Surg Oncol. 2014 Jun;21 Suppl 3:S398-404. doi: 10.1245/s10434-014-3578-9. Epub 2014 Feb 25.