Clinical trial · Interventional
Reducing Cognitive Impairment in Glioma with Repetitive Transcranial Magnetic Stimulation and Cognitive Strategy Training
TRUE-GRIT: Reducing Cognitive Impairment in Glioma with Repetitive Transcranial Magnetic Stimulation and Cognitive Strategy Training
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The TRUE-GRIT study will assess the feasibility of a study protocol investigating the efficacy of a combination therapy consisting of cognitive strategy training (CST) and repetitive transcranial magnetic stimulation (rTMS) to reduce cognitive impairment in adult glioma patients. This study is part of the GRIP-project, a project aimed at investigating interventions for improving quality of life in brain tumor patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Impairment | — | UNRESOLVED | — |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cognitive strategy training | Behavioral | — | UNRESOLVED |
| real repetitive transcranial magnetic stimulation (rTMS) | Device | — | UNRESOLVED |
| sham repetitive transcranial magnetic stimulation (rTMS) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cognitive strategy training + real rTMS
- description
- Verum rTMS to PPC contralateral to the tumor (3000 10Hz pulses at 110% RMT, 30 10-s trains, 30s inter-trial interval, 20 mins total)
- interventionNames
- Device: real repetitive transcranial magnetic stimulation (rTMS)
- Behavioral: cognitive strategy training
- type
- SHAM_COMPARATOR
- label
- Cognitive strategy training + sham rTMS
- description
- Sham rTMS to PPC contralateral to the tumor (3000 10Hz pulses at 110% RMT, 30 10-s trains, 30s inter-trial interval, 20 mins total).
- interventionNames
- Device: sham repetitive transcranial magnetic stimulation (rTMS)
- Behavioral: cognitive strategy training
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * ≥ 18 years of age * Histological diagnosis of diffuse glioma (WHO grade 2,3, or 4) * Subjective cognitive impairment, defined as CFQ-score ≥ 44 * Being able to give informed consent and undergo treatment and measurements based on researchers insight * Stable disease, i.e. no oncological treatment for ≤ 2 months prior to inclusion; no radiological progression on the most recent MRI, not older than 6 months, and no clinical progression at inclusion * Stable dosage (for at least 8 weeks) of anti-epileptic medication Exclusion Criteria: * Current pregnancy or have given birth less than three months ago * Current other treatment for cognitive complaints * Karnofsky performance score \<70 * A tumor located in the parietal cortex * TMS exclusion: implanted medical devices (e.g. pacemaker, deep brain stimulator, cochlear implants, medical infusion device, etc.); metal in the body; sleep deprivation * MRI exclusion: extreme claustrophobia or metallic objects in or on the body
References
Publications (0)
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