Comparison of Sublobar and Lobectomy in Small (2 Cm or Less 0.5<CTR<1) Non-small Cell Lung Cancer: a Prospective, Multicenter Randomized Controlled Study

Inclusion Criteria:

* nitial inclusion criteria:

  1. Age 18-75 years old, regardless of gender;
  2. ECOG PS score 0-1 points (Attachment 3.4);
  3. Preoperative clinical staging for patients with suspected NSCLC lesions in Phase I (according to AJCC Eighth Edition staging standards, Attachment 3.5);
  4. Thin slice CT indicates that the maximum tumor diameter is ≤ 2.0cm;
  5. Pre operative CT prompts 0.5\<CTR\<1.0;
  6. Good lung function (FEV1\>1.5 L or FEV1% ≥ 60%), able to tolerate both segmental resection and lobectomy;
  7. The number of pulmonary nodules that need to be processed is ≤ 3, and the nodules are located in the same side of the lung;
  8. Those who voluntarily sign the research informed consent form can comply with the research visit plan and other protocol requirements.

     Exclusion Criteria:

Initial exclusion criteria:

1. Hypertension and diabetes difficult to control;
2. Pregnant or lactating women;
3. Those who have received anti-tumor treatment (radiotherapy, chemotherapy, Targeted therapy, immunotherapy) before surgery;
4. Previous history of lung surgery;
5. Interstitial pneumonia, Pulmonary fibrosis or severe Emphysema;
6. Those who undergo thoracotomy or change the surgical plan due to various reasons during surgery;
7. Severe mental illness;
8. Individuals with a history of severe heart disease, heart failure, myocardial infarction, or angina within the past 6 months;
9. Active bacterial or fungal infections that are difficult to control;
10. Individuals who have conducted other clinical trials in the three months prior to enrollment.

Secondary exclusion criteria:

1. The postoperative pathological result was Benign tumor;
2. Postoperative pathological results of non NSCLC malignant tumors;
3. Non small cell lung cancer confirmed histologically during operation, but with malignant Pleural effusion and pleural dissemination