Clinical trial · Observational
Assessment of Hypoxia Before Radioembolization Treatment With 18F-FMISO PET
NCT06027021CI-TRIAL-00079258ARTE-MISOcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hypoxia is a known factor for resistance to radiotherapy in tumors. Response to transarterial radioembolization is known to be variable between different patients even if the same dose of radiation was delivered. In this study the investigators aim to quantify the hypoxia in the primary and secondary tumors of liver with 18F-FMISO PET before radioembolization and to prove any effect of the hypoxia, if present, on the dose that should be delivered to tumor to ensure treatment response.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Positron Emission Tomography | — | UNRESOLVED | — |
| Radioembolization | — | UNRESOLVED | — |
| Radiotherapy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 18F-Fluoromisonidazole PET | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Treatment group
- description
- Patients received radioembolization with hepatocellular cancer or colorectal cancer liver metastases
- interventionNames
- Diagnostic Test: 18F-Fluoromisonidazole PET
Primary outcomes (2)
- measure
- Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
- timeFrame
- 08/2024
- description
- Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
- measure
- The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group.
- timeFrame
- 08/2024
- description
- The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with colorectal carcinoma with liver metastasis or hepatocellular carcinoma. * Is not eligible for surgery * Above 18 years old * The patients who are referred for transarterial radioembolization treatment to Ankara University School of Medicine Department of Nuclear Medicine. Exclusion Criteria: * Patients with ECOG performance score \>1 * Claustrophobia * Life expectancy shorter than 3 months * Pregnant or breast-feeding patients
References
Publications (0)
Data not yet available
No reference posted for this study.