L. Plantarum 299v and Gut Microbiome, Diarrhoea, and Clostridioides Difficile Infection in Colorectal Cancer Patients

Colorectal cancer in periooperative period patients (n=60) will be enrolled to this study. Participants will be divided into 4 groups as follows: * group 1 (n=15) will receive 2 capsules (per day) of L. plantarum 299v L. plantarum 299v (Sanprobi IBS®) for 4 weeks * group 2 (n=15) will receive L. plantarum 299v (2 capsules per day) and inulin (4 g) for 4 weeks * group 3 (n=15) will receive placebo (2 capsules per day) and inulin (4 g) for 4 weeks * group 4 (n=15) will receive placebo (2 capsules per day) for 4 weeks

Sex

All

Minimum age

18 Years

Maximum age

65 Years

Inclusion Criteria:

* age ≥18 oraz ≤65
* patients with colorectal cancer prior to surgical treatment
* qualification to surgery
* the treatment with chemotherapy and radiotherapy in preoperative period
* an appropriate swallowing
* patients agreement to take part in this study

Exclusion Criteria:

* the presence of other cancers than colorectal cancer
* inflammatory bowel diseases
* dysphagia
* intake of antibiotics, proton pump inhibitors, probiotics, and synbiotics 3 months befor taking part in this study