Clinical trial · Observational
Arm Exercise Capacity and Maximal Oxygen Consumption With Breast Cancer
Arm Function in Breast Cancer Survivors: Is There a Decrease in Maximal Capacity and Oxygen Utilization?
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Breast cancer is the most common type of cancer among women worldwide. The incidence rate has reached approximately 16%. According to 2016 data from the Ministry of Health, the incidence of breast cancer in Turkey is 46.8 per 100,000 people and approximately 17,000 women are diagnosed with breast cancer each year. While breast cancer survival rate is 80% in developed countries, this rate varies between 40-60% in low-middle income countries. Survival can be increased with early diagnosis and more effective treatment methods. However, a wide range of treatment-related complications are observed during and/or after breast cancer treatment. Cancer survivors are exposed to a variety of direct (local/regional therapy, systemic therapy and supportive care) and indirect factors (modifiable and non-modifiable risk factors) that can have adverse effects on pulmonary, cardiovascular, hematologic and musculoskeletal components. Oxygen consumption in cancer patients may be adversely affected by aging, deconditioning, existing comorbidities, cancer pathophysiology and cancer treatments (surgery, radiation, chemotherapy and hormone therapy). Although decreased functional capacity is common after breast cancer treatment, there are few studies evaluating maximal arm exercise capacity with oxygen consumption.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Healthy | — | UNRESOLVED | — |
| Oxygen Consumption | — | UNRESOLVED | — |
| Upper Extremity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak) | Diagnostic Test | — | UNRESOLVED |
| Muscle oxygenation | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Breast Cancer Group
- description
- Inclusion criteria for BCS were as follows: an age between 18 and 65 years; diagnosis of stage I-III BC; individuals with unilateral BC; ≥ 15 months must have passed since BC surgery; participants must have completed active cancer treatment (CT and/or RT) ≥ 6 months prior to joining the study; absence of BCRL; ability to read and understand questionnaires; and ability to cooperate with the assessments. Exclusion criteria for BCS included the presence of active infection, presence of BCRL; musculoskeletal or neurological conditions affecting exercise performance, symptomatic cardiovascular disease, neurological disorders, or any condition that could impair cognitive function.
- interventionNames
- Diagnostic Test: Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak)
- Diagnostic Test: Muscle oxygenation
- label
- Control Group
- description
- Inclusion criteria for healthy controls were an age between 18 and 65 years, the willingness to participate, the ability to read and understand questionnaires, and the ability to cooperate with the assessments. Exclusion criteria for healthy controls were the presence of orthopedic or neuromuscular conditions, chronic diseases, psychiatric or other mental conditions that could interfere with exercise testing.
- interventionNames
- Diagnostic Test: Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 15 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: Breast Cancer Group: 1. Being between 18-65 years of age, 2. Volunteering to participate in the research, 3. Stage I-III breast cancer, 4. At least 15 months after breast cancer surgery, 5. Six months after active breast cancer treatment (i.e. surgery/chemotherapy), 6. No lymphedema 7. No problems in reading and/or understanding the scales and being able to cooperate with the tests, Healthy group: 1. Age between 18-65 years, 2. Volunteering to participate in the research, 3. No problems in reading and/or understanding the scales and being able to cooperate with the tests. Exclusion Criteria: Breast Cancer Group: 1. Presence of active infection, 2. Musculoskeletal and neurological diseases that may affect exercise performance, symptomatic heart disease, 3. Having a neurological disease or other clinical diagnosis that may affect cognitive status. Healthy group: 1. Having any orthopedic or neuromuscular condition that would interfere with walking or exercise performance, 2. Having any chronic disease or psychiatric disorders or mental impairments that may interfere with cooperation or compliance with exercise tests
References
Publications (0)
Data not yet available