Clinical trial · Interventional
MRI-based Synthetic CT Images of the Head and Neck
Artificial Intelligence Driven Synthetic CT to Substitute CT Scans of the Head and Neck Region
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment. An important downside of a CT scan is the associated radiation exposure, especially in children. An additional downside is the sedation or general anaesthesia needed for both the MRI and CT scan session in very young children. These downsides could be removed if the CT scan can be substituted by an MRI sequence that can provide the same information as CT. This project aims to determine the feasibility of recreating CT like images of the craniofacial bones from MRI images using machine learning techniques.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cholesteatoma | — | UNRESOLVED | — |
| Head and Neck Tumor | Head and Neck Neoplasm | ALIAS | 0.90 |
| Hearing Loss | — | UNRESOLVED | — |
| Imaging of Bony Structures of the Head (Various Conditions) | — | UNRESOLVED | — |
| Sinusitis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT scan | Diagnostic Test | — | UNRESOLVED |
| MRI scan | Diagnostic Test | — | UNRESOLVED |
| Synthetic CT scan | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Training
- description
- Data from 25-35 participants will be used to train an algorithm to generate synthetic CT images from MRI scans.
- interventionNames
- Diagnostic Test: CT scan
- Diagnostic Test: MRI scan
- type
- OTHER
- label
- Testing
- description
- Data from remaining participants will be used to test the synthetic CT algorithm, by comparing true CT scans to synthetic CT scans made from MRI.
- interventionNames
- Diagnostic Test: CT scan
- Diagnostic Test: MRI scan
- Other: Synthetic CT scan
Primary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients from the outpatient ENT (Ear, Nose, Throat)-clinic. * Aged 18 years or older. * Referred for CT scan of the mastoid, sinonasal complex or face. Exclusion Criteria: * Pregnancy. * Contra-indications for MRI or CT. * Unwillingness to be informed about possibly clinically relevant, incidental findings from the MRI examination.
References
Publications (0)
Data not yet available