Clinical trial · Interventional
Game Changers for Cervical Cancer Prevention
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention in Uganda
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial will evaluate Game Changers for Cervical Cancer Prevention (GC-CCP) for increasing cervical cancer (CC) screening advocacy among intervention recipients (index participants) towards female social network members, and uptake of CC screening among enrolled female social network members (alter participants) who have not previously been screened. The main research questions are: 1. Is the GC-CCP network-based peer advocacy intervention superior to usual care (no intervention) in improving uptake of CC screening among alter participants, across urban/rural and public/private clinics? 2. What are the mediators and moderators (among index, alter and network characteristics) of intervention effects on (a) alter CC screening; and (b) engagement in CC prevention advocacy among index participants?
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Game Changers for Cervical Cancer Prevention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Advocacy Training Intervention
- description
- 6 weekly group sessions of advocacy training for cervical cancer screening
- interventionNames
- Behavioral: Game Changers for Cervical Cancer Prevention
- type
- NO_INTERVENTION
- label
- Usual care control
- description
- usual care (no intervention); control participants will be offered the chance to receive the intervention at the conclusion of month 12 follow-up data collection
Primary outcomes (1)
- measure
- Number of alter participants that has received cervical cancer screening
- timeFrame
- past 6 months
- description
- Receipt of screening via visual inspection of cervix with acetic acid (VIA), among enrolled alter participants
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * screened for cervical cancer in the past year (index participants only) * has shared cervical cancer screening experience with at least one adult female social network member whom is believed to not have been screening for cervical cancer; or she reports that there is at least one female social network member who has not screened and she would feel comfortable disclosing her personal screening experience to her (index participants only) * is a member of social network of enrolled participant (social network member participants only) Exclusion Criteria: * advanced stage cervical cancer (index participants only) * screened for cervical cancer in the past (1st degree social network member participants only)
References
Publications (1)
- DERIVEDWagner GJ, Bogart LM, Matovu JKB, Gwokyalya V, Beyeza-Kashesya J, Ober A, Green HD, Nakami S, Juncker M, Namisango E, Luyirika E, McBain RK, Bouskill K, Wanyenze RK. Study protocol for a hybrid implementation-effectiveness trial of Game Changers for Cervical Cancer Prevention in Uganda. PLoS One. 2025 Jan 24;20(1):e0317491. doi: 10.1371/journal.pone.0317491. eCollection 2025. PMID 39854403