Clinical trial · Interventional
Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function
Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Function | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| acetaminophen mannitol | Drug | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- By applying acetaminophen mannitol to patients with gastrointestinal tumors before surgery
- description
- Acetaminophen mannitol injection 50ml(500mg) intravenously pumped 30 minutes before surgery
- interventionNames
- Drug: acetaminophen mannitol
- type
- PLACEBO_COMPARATOR
- label
- By applying normal saline to patients with gastrointestinal tumors before surgery
- description
- Normal saline injection 50ml intravenously pumped 30 minutes before surgery
- interventionNames
- Drug: Normal saline
Primary outcomes (1)
- measure
- Postoperative delirium
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
- Maximum age
- 88 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing gastrointestinal tumor surgery * American Society of Anesthesiologists（ASA）≤Ⅲ Exclusion Criteria: * History of severe adverse reactions to oral acetaminophen * Dysfunction of heart, liver, kidney and other important organs * History of chronic pain * Oral non-steroidal or opioid drugs * Patients who do not accept clinical trials
References
Publications (0)
Data not yet available