Clinical trial · Observational
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy (SATIATION)
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy. The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and more studies are calling for the use of dosimetric parameters related to cardiac sub-structures to be integrated into clinical practice, rather than considering the heart as a whole. With this in mind, the aim of this study is to define the parameters, particularly dosimetric ones linked to cardiac sub-structures, influencing survival in patients treated with exclusive radiotherapy or radiochemotherapy for esophageal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophagus Cancer | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Overall survival (OS)
- timeFrame
- through study completion, an average of 1 year
- description
- OS is defined as the time elapsed between inclusion and death, whatever the cause.
Secondary outcomes (3)
- measure
- The rate of cardiac events.
- timeFrame
- through study completion, an average of 1 year
- description
- The rate of cardiac events.
- measure
- Response rate.
- timeFrame
- through study completion, an average of 1 year
- description
- Response rate.
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 years * Histologically or cytologically proven esophageal cancer * Localized or locally advanced esophageal cancer treated with radiochemotherapy or exclusive radiotherapy * Tumor dose ≥ 50 Gy * Non-opposition of living patients formulated * Patient affiliated to a social security scheme Exclusion Criteria: * Age \< 18 years * Patient treated with upfront surgery * Tumor dose \< 50 Gy * Other concomitant neoplasia * Metastatic patient * Refusal to participate * Patient under legal protection (guardianship, curatorship, etc...)
References
Publications (0)
Data not yet available