Clinical trial · Observational
Analysis of CMTM6 Expression in Patients With Acute Myeloid Leukemia
NCT05988047CI-TRIAL-00076931completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study, we aim to investigate the expression of CKLF like MARVEL transmembrane domain containing 6 (CMTM6) in leukemia cells of patients with acute myeloid leukemia (AML). We will use peripheral blood samples and assess CMTM6 expression by flow cytometry and Western Blot.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Myeloid Leukemia, Adult | Adult Acute Myeloid Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Patients with AML
- description
- Peripheral blood will be taken at the timepoint of primary diagnosis and analyzed for CMTM6 expression and T cell activation
- label
- Healthy controls
- description
- Peripheral blood will be taken analyzed for CMTM6 expression and T cell activation
Primary outcomes (2)
- measure
- CMTM6 expression (FC)
- timeFrame
- At primary diagnosis
- description
- CMTM6 expression on blasts/monocytes will be measured by flow cytometry
- measure
- T cell activation (FC)
- timeFrame
- At primary diagnosis
- description
- T cell activation and cytokine production will be measured by flow cytometry
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥ 18 years * primary diagnosis of acute myeloid leukemia * diagnosis results available * written informed consent * ability to understand the nature of the study and the study related procedures and to comply with them Exclusion Criteria: * age \< 18 years * lack of informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.