Clinical trial · Observational
Long-term Use of CCB and Breast Cancer Risk
Association of Long-term Use of Calcium Channel Blockers (CCB) and Risk of Breast Cancer: A Retrospective Longitudinal Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this retrospective observational study is to examine whether long-term calcium channel blocker (CCB) use is associated with the development of breast cancer amongst women enrolled in three longitudinal cohort studies in Australia and the Netherlands . The main questions it aims to answer are: * Is long-term CCB use associated with the development of breast cancer amongst women enrolled in three longitudinal cohort studies in Australia and the Netherlands and what is the dose-response nature of this association. * Does differences in the association between calcium channel blocker use and the development of breast cancer exist between Australian and Dutch women. The investigators will utilise data from the Australian Longitudinal Study on Women's Health (ALSWH) , 45 and Up Study and Rotterdam study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Hypertension,Essential | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Beta blocker | Drug | — | UNRESOLVED |
| Calcium channel blocker | Drug | — | UNRESOLVED |
| Diuretic | Drug | — | UNRESOLVED |
| None AHT | Drug | — | UNRESOLVED |
| Other AHT | Drug | — | UNRESOLVED |
| RAS | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- No AHT
- description
- Women with HTN with no AHT use
- interventionNames
- Drug: None AHT
- label
- AHT but non-CCB
- description
- Women with HTN exposed to other antihypertensive medicines but not exposed to calcium channel blockers
- interventionNames
- Drug: Beta blocker
- Drug: Diuretic
- Drug: RAS
- Drug: Other AHT
- label
- CCB only
- description
- Women with HTN exposed to calcium channel blockers but not exposed to other antihypertensive medicines
- interventionNames
- Drug: Calcium channel blocker
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 45 Years
Show eligibility criteria text
Inclusion criteria: * Alive and still enrolled in the longitudinal cohort at the study entry (2004 to 2009) * Self-reported/diagnosed hypertension at study entry. Exclusion criteria: \+ A history of breast cancer.
References
Publications (1)
- DERIVEDHo C, Ha NT, Youens D, Abhayaratna WP, Bulsara MK, Hughes JD, Mishra G, Pearson SA, Preen DB, Reid CM, Ruiter R, Saunders CM, Stricker BH, van Rooij FJA, Wright C, Moorin R. Association between long-term use of calcium channel blockers (CCB) and the risk of breast cancer: a retrospective longitudinal observational study protocol. BMJ Open. 2024 Mar 8;14(3):e080982. doi: 10.1136/bmjopen-2023-080982. PMID 38458796