A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Head and Neck Cancer

Inclusion Criteria:

1. Head and neck cancer patients

   * Age 18-75 years old;
   * Male or non-pregnant female;
   * Patients who were normatively diagnosed as head and neck tumors according to the WHO standards of 2017;
   * The general situation is good: KPS score ≥70;
   * No other malignant tumors.
2. Healthy people

   * Age 18-75 years old;
   * Male or non-pregnant female;
   * No history of head and neck related diseases or other diseases known to affect blood lipid/protein metabolism.

Exclusion Criteria:

* Previous history of non-research related head and neck conditions or other known effects on blood metabolism (except for controlled type 2 diabetes);
* With a history of other malignancies (except cell carcinoma and cervical carcinoma in situ);
* Diseases that require long-term use of immunosuppressive drugs (including steroids), including but not limited to congenital or acquired immunodeficiency disorders or active central nervous system rotations, metastatic cancer, active infection, or uncontrolled heart disease;
* Concurrent with other uncontrolled serious medical conditions, such as unstable heart disease that requires treatment Disease, poorly controlled diabetes (fasting blood glucose \> 1.5× the upper limit of normal), mental illness and a history of severe allergies.
* BMI less than 18 or greater than 25.