Clinical trial · Interventional
The Incidence of Gallstones After Gastrectomy
Effect of Gastric Cancer Surgical Resection Extent on Postoperative Gallstone Formation: A Retrospected Cohort Study
NCT05965466CI-TRIAL-00082720completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the Roux-en-Y reconstruction modality in radical gastric cancer surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gallstone | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Distal gastrectomy and radical resection | Procedure | — | UNRESOLVED |
| Total gastrectomy and radical resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Distal gastrectomy
- description
- Distal subtotal gastrectomy was performed after exclusion of contraindications to surgery. Gastrointestinal reconstruction was performed by residual gastrojejunal Roux-en-Y anastomosis. Anastomosis was performed ex vivo or in vivo.
- interventionNames
- Procedure: Distal gastrectomy and radical resection
- type
- SHAM_COMPARATOR
- label
- Total gastrectomy
- description
- Total gastrectomy was performed after the exclusion of contraindications to surgery. Gastrointestinal reconstruction was performed by oesophageal jejunum Roux-en-Y anastomosis. Anastomosis was performed ex vivo or in vivo.
- interventionNames
- Procedure: Total gastrectomy and radical resection
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with Gastric Cancer underwent Gastrectomy Exclusion Criteria: * Age less than 18 years or age greater than 75 years; * Not Roux-en-Y reconstruction; * R0 excision is not achieved; * Previous history of upper abdominal surgery, such as cholecystectomy, gastrectomy; * Preoperative gallbladder diseases, such as gallstones, gallbladder polyps, chronic cholecystitis; * Preoperative neoadjuvant chemotherapy or radiotherapy; * Previous history of malignant tumours; * Patients with mental or developmental abnormalities or women during pregnancy or breastfeeding; * Gastric perforation or bleeding leading to emergency surgery; * Palliative surgical treatment; * Incomplete case information.
References
Publications (3)
- RESULTPark DJ, Kim KH, Park YS, Ahn SH, Park do J, Kim HH. Risk Factors for Gallstone Formation after Surgery for Gastric Cancer. J Gastric Cancer. 2016 Jun;16(2):98-104. doi: 10.5230/jgc.2016.16.2.98. Epub 2016 Jun 24. PMID 27433395
- RESULTWu CH, Huang KH, Chen MH, Fang WL, Chao Y, Lo SS, Li AF, Wu CW, Shyr YM. Comparison of the Long-term Outcome Between Billroth-I and Roux-en-Y Reconstruction Following Distal Gastrectomy for Gastric Cancer. J Gastrointest Surg. 2021 Aug;25(8):1955-1961. doi: 10.1007/s11605-020-04867-1. Epub 2020 Nov 17. PMID 33205309
- DERIVEDZhang B, Nie P, Lin Y, Ma Z, Ma G, Wang Y, Ma Y, Zhao J, Zhang J, Yue P, Jiang N, Zhang X, Tian L, Lu L, Yuan J, Meng W. High incidence of gallstones after Roux-en-Y reconstruction gastrectomy in gastric cancer: a multicenter, long-term cohort study. Int J Surg. 2024 Apr 1;110(4):2253-2262. doi: 10.1097/JS9.0000000000001136. PMID 38320088