Clinical trial · Interventional
Multimodal Prehabilitation for Lung Cancer Surgery
A Novel Multimodal Intervention for Surgical Prehabilitation of Patients With Lung Cancer: the MMP-LUNG Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main objective of this randomized controlled trial (RCT) is to investigate whether a multimodal prehabilitation intervention combining a mixed-nutrient supplement with structured exercise training (MM) or the supplement alone (NUT), against a placebo (CTRL), leads to improvement in functional capacity and postoperative outcomes in surgical patients with lung cancer, at nutritional risk. This will be tested in a single centre RCT of 3 parallel arms, double-blinded for the supplement. Female and male participants (n=168, \>=45 y) will be randomized to a 10-week intervention spanning 4 weeks pre-surgery and 6 weeks post-hospital discharge. The primary outcome is functional capacity as measured by the 6-minute walk test. Secondary outcomes include muscle mass, quality and strength, quality of life, length of hospital stay, and postoperative complications.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mixed-nutriend supplement (NUT) | Dietary Supplement | — | UNRESOLVED |
| Multimodal Prehabilitation (MM) | Other | — | UNRESOLVED |
| Placebo Control (CTRL) | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Control (CTRL)
- description
- Participants will be treated following Enhanced Recovery After Surgery (ERAS) protocols + placebo supplements containing maltodextrin and sunflower oil
- interventionNames
- Dietary Supplement: Placebo Control (CTRL)
- type
- ACTIVE_COMPARATOR
- label
- Mixed-nutriend supplement (NUT)
- description
- Mixed nutrient supplement containing whey protein, leucine, vitamin D and omega 3 fatty acids
- interventionNames
- Dietary Supplement: Mixed-nutriend supplement (NUT)
- type
- ACTIVE_COMPARATOR
- label
- Multi-modal intervention (MM)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 45 years and over * Diagnosed with NSCLC stages I, II or IIIa and scheduled for video-assisted thoracic surgery (VATS) or open thoracotomy surgery for cancer resection * At nutritional risk (defined as Patient Generated-Subjective Global Assessment score = or \>3) Exclusion Criteria: * Prior recent (\<2 months) adjuvant therapy (chemo- or radio-therapy) * Inability to perform, or comorbidities contraindicating, exercise (defined as CPET \<10 mL O2/kg/min) * Unable to walk (uses a wheelchair) * Allergy to milk or seafood * Hypercalcemia (total serum Ca \>2.60 mmol/L or ionized Ca \>1.30 mmol/L) * Hypervitaminosis D (serum 25(OH)D \>375 nmol/L) * Glomerular filtration rate (\<30 mL/min/1.73m2) * Insufficient understanding of English or French to provide informed consent Patients taking omega-3 FA supplements will be asked to withhold them during the study; those taking vitamin D will continue unless baseline serum 25(OH)D \>80 nmol/L.
References
Publications (1)
- DERIVEDMoyen A, Fleurent-Gregoire C, Gillis C, Zaks R, Carli F, Scheede-Bergdahl C, Spicer J, Cools-Lartigue J, Najmeh S, Morais JA, Mazurak V, Chevalier S. Novel multimodal intervention for surgical prehabilitation on functional recovery and muscle characteristics in patients with non-small cell lung cancer: study protocol for a randomised controlled trial (MMP-LUNG). BMJ Open Respir Res. 2025 May 22;12(1):e002884. doi: 10.1136/bmjresp-2024-002884. PMID 40404185