Clinical trial · Interventional
Effects of Dexamethasone on Common Bile Duct Cannulation Time
Can Deep Common Bile Duct Cannulation Time During Endoscopic Retrograde Cholangiopancreatography Be Shortened by Dexamethasone
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main aim of this clinical trial is to evaluate the effects of dexamethasone on common bile duct cannulation time during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary pathologies. The study will also study the effects of dexamethasone on total procedure time and total fluoroscopy time during ERCP. Participants will be divided into two groups, treatment group and placebo group. Patients in treatment group will receive dexamethasone and those in placebo group will be given normal saline before undergoing ERCP. The results in both groups will be compared to determine the effects of dexamethasone.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Common Bile Duct Calculi | — | UNRESOLVED | — |
| Common Bile Duct Dilatation | — | UNRESOLVED | — |
| Common Bile Duct Diseases | — | UNRESOLVED | — |
| Common Bile Duct Neoplasms | — | UNRESOLVED | — |
| Common Bile Duct Stricture | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone 4mg | Drug | Dexamethasone | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dexa Arm
- description
- Experimental arm patients will be receiving 2 ml (4mg) of dexamenthasone prior to undergoing ERCP.
- interventionNames
- Drug: Dexamethasone 4mg
- type
- PLACEBO_COMPARATOR
- label
- NS Arm
- description
- Placebo arm patients will be receiving 2 ml of normal saline prior to undergoing ERCP.
- interventionNames
- Drug: Dexamethasone 4mg
Primary outcomes (1)
- measure
- Shortening of CBD cannulation time
- timeFrame
- CBD cannulation time will be calculated from the start of the procedure (0 minutes) till complete CBD cannulation has been achieved through catheter and confirmed by fluoroscopy or procedure abandoned if unsuccessful cannulation by 30 minutes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age: 18 years or above * Both genders, male and female patients Exclusion Criteria: * Age younger than 18 years or below * Pregnant females * Pre existing stent in CBD or pancreatic duct * Previous history of ERCP * Patients with billroth II surgery * Anatomical abnormalities * Lack of competence in patients * Roux en Y gastric bypass * Patients with contra indications for steroids like DM
References
Publications (5)
- BACKGROUNDSherman S, Lehman GA. Endoscopic retrograde cholangiopancreatography, endoscopic sphincterotomy and stone removal, and endoscopic biliary and pancreatic drainage. In: Yamada T, et al. (eds.) Text book of gastroenterology. 3rd edn. Philadelphia: Lippincott, Williams & Wilkins ; 1999: 2718 - 2746
- BACKGROUNDWehrmann T, Schmitt T, Stergiou N, Caspary WF, Seifert H. Topical application of nitrates onto the papilla of Vater: manometric and clinical results. Endoscopy. 2001 Apr;33(4):323-8. doi: 10.1055/s-2001-13687. PMID 11315893
- BACKGROUNDAllescher HD, Neuhaus H, Hagenmuller F, Classen M. Effect of N-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP--a manometric study. Endoscopy. 1990 Jul;22(4):160-3. doi: 10.1055/s-2007-1012829. PMID 2209497
- BACKGROUNDSola-Bonada N, de Andres-Lazaro AM, Roca-Massa M, Bordas-Alsina JM, Codina-Jane C, Ribas-Sala J. [1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography]. Farm Hosp. 2012 Jul-Aug;36(4):256-60. doi: 10.1016/j.farma.2011.08.003. Epub 2011 Dec 1. Spanish. PMID 22137159
- BACKGROUNDDevereaux BM, Lehman GA, Fein S, Phillips S, Fogel EL, Sherman S. Facilitation of pancreatic duct cannulation using a new synthetic porcine secretin. Am J Gastroenterol. 2002 Sep;97(9):2279-81. doi: 10.1111/j.1572-0241.2002.05982.x. PMID 12358245