Clinical trial · Interventional
Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer
Establishment of a Network Platform for Fertility-sparing in Patients With Endometrial Cancer and Study on Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to explore the feasibility and outcome of fertility-sparing therapy in Stage IA G1-G2 Endometrial Cancer with less than 1/2 myometrial invasion. Researchers will render participants indication-extended fertility-sparing therapy. Researchers will compare the myometrial invasion group with the no myometrial invasion group to see if it is possible to propose an extension indication of fertility-sparing therapy for endometrial cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Endometrioid | Endometrioid Adenocarcinoma | ALIAS | 0.90 |
| Endometrial Neoplasm Malignant | — | UNRESOLVED | — |
| Endometrial Neoplasm Malignant Stage I | — | UNRESOLVED | — |
| Endometrial Neoplasms | Endometrial Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Fertility Preservation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Indication-extended Fertility-sparing Therapy | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Myometrial invasion group
- description
- Pelvic enhanced magnetic resonance imaging or transvaginal color Doppler ultrasound suggests that the tumor invades less than one half of the myometrium.
- interventionNames
- Combination Product: Indication-extended Fertility-sparing Therapy
- type
- OTHER
- label
- No myometrial invasion group
- description
- Pelvic enhanced magnetic resonance imaging or transvaginal color Doppler ultrasound suggests that the tumor is limited to the endometrium.
- interventionNames
- Combination Product: Indication-extended Fertility-sparing Therapy
Primary outcomes (1)
- measure
- complete remission rate
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Stage IA (FIGO 2009) ; * Pathological diagnosis: endometrial adenocarcinoma G1-G2; * MRI or ultrasound: tumor limited to endometrium or invading less than 1/2 of myometrium； * 18 years old ≤ Age ≤ 45 years old; * With a strong desire for fertility preservation； * Sign the informed consent. Exclusion Criteria: * Complicated with any other malignancy； * Contraindications to conservative treatment； * Contraindications to progestin use; * Contraindications to pregnancy, or judged by the researcher to be unfit for pregnancy or delivery.
References
Publications (0)
Data not yet available