Clinical trial · Observational
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling
NCT05943262CI-TRIAL-00079967recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research aims to develop a novel pathological technology, including rapid whole-mount tissue H\&E \& IHC staining protocol and high-resolution nonlinear optical microscopy imaging system, to intraoperatively assess brain tumor grade, types and other biological parameters.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Cancer | Malignant Brain Neoplasm | ALIAS | 0.90 |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| mesoscale nonlinear optical microscope | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- mesoscale nonlinear optical microscope + whole-mount H&E & IHC staining protocol
- interventionNames
- Device: mesoscale nonlinear optical microscope
Primary outcomes (2)
- measure
- Develop a standard whole-mount tissue processing protocol
- timeFrame
- 3 years
- description
- In this research, the investigators will try to create a standard staining protocol to perform rapid whole-mount H\&E and IHC staining on surgical brain tumor specimens, so that the cell morphology (ex: cell shape, cell size, etc) and cell types (ex: astrocytes, oligodendrocytes, T-cells, B-cells, etc) in the images of those tissues can be observed via nonlinear optical microscopy, and the treatment strategy can be set based on subtyping and grading the brain tumors by the pathologists.
- measure
- Obtain images from H&E and IHC stained brain tumor tissues by nonlinear optical microscopy
- timeFrame
- 3 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Patients older than the age of 20 with diagnosis of brain tumor (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery. Exclusion Criteria: 1. Patients who cannot give consent to participate in the study. 2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow. 3. Patients who only receives biopsy surgery rather than resection surgery. 4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
References
Publications (0)
Data not yet available
No reference posted for this study.