Clinical trial · Interventional
Physical Exercise and Dairy Probiotics in Childhood Cancer Survivors
The Effect of Physical Exercise and Dairy Probiotics (Lactobacillus Casei) on Gut Microbiome in Childhood Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to to compare the structure of the intestinal microbiome between children shortly after treatment for acute lymphoblastic leukemia (1-3 years after cancer treatment) and healthy controls. And then to provoke a positive shift of bacterial diversity by physical activity and probiotics in cured pediatric oncology patients with persistent gut microbiome disruptions. The main question\[s\] it aims to answer are: * Are differences in bacterial richness between healthy controls and pediatric oncology patients ≥12 months after cancer treatment apparent? * Has the combination of physical exercise and probiotics had a positive influence on the structure of the gut microbiome in childhood cancer survivors in remission? Two times per week of physical activity and daily dairy consumption with probiotics will be required of participants for eight weeks.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia, Pediatric | Childhood Acute Lymphoblastic Leukemia | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lacticaseibacillus paracasei subsp. Paracasei CNCMI-1518 | Other | — | UNRESOLVED |
| Physical exercise | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise training
- description
- Children previously diagnosed and treated for acute lymphoblastic leukemia in remission between 1 and 3 years with physical exercise intervention
- interventionNames
- Other: Lacticaseibacillus paracasei subsp. Paracasei CNCMI-1518
- Other: Physical exercise
- type
- NO_INTERVENTION
- label
- Passive
- description
- Children previously diagnosed and treated for acute lymphoblastic leukemia in remission between 1 and 3 years without physical exercise intervention
Primary outcomes (1)
- measure
- The shift of gut microbiome by physical exercise and consumption of dairy probiotics.
- timeFrame
- 8 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: \- children previously diagnosed and treated for acute lymphoblastic leukemia in remission between 1 and 3 years Exclusion Criteria: * acute respiratory infection during intervention * more than 20% skipped exercise training sessions
References
Publications (0)
Data not yet available