Clinical trial · Interventional
Impact of Respiratory Training in Lymphoma Survivors
The Impact of Inspiratory Muscle Strength Training and Personalized Exercise Prescription on Metabolism, Cardiovascular Function, and Cardiorespiratory Fitness in Lymphoma Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Low Accrual
Summary
Brief summary (as posted)
High-resistance inspiratory muscle strength training (IMST) is a time-efficient (\~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hodgkin Lymphoma | Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Non Hodgkin Lymphoma | Non-Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Inspiratory muscle strength training | Device | — | UNRESOLVED |
| Sham Inspiratory muscle strength training | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pre-Randomization
- description
- Participants who withdrew from the study prior to group randomization (prior to visit 2).
- interventionNames
- Device: Inspiratory muscle strength training
- Device: Sham Inspiratory muscle strength training
Primary outcomes (6)
- measure
- Total Participants Recruited
- timeFrame
- 12 weeks
- description
- Count of number of participants recruited into the study
- measure
- Enrolled Participants Per Month
- timeFrame
- 12 weeks
- description
- Average number of participants enrolled per month of the study
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 - 80 * Primary cancer diagnosis of lymphoma * Able and willing to participate in a supervised exercise program at the Anschutz Health and Wellness Center * Provides a signed physician exercise clearance form * SBP \> 120 mmHg * Completion of curative cancer treatment over 12 months prior (individuals on maintenance therapy will be included) * Possession of a smartphone compatible with the IMST training application (available on both Android and Apple). Exclusion Criteria: * oSecond active cancer diagnosis * oPlanned active cancer treatment or change in current treatment in the next 6 months * Severe obesity (BMI \>; 40 kg/m2) or underweight (BMI \<18.5 kg/m2) * Unstable weight (\>; 3 kg change in body mass in last 3 months) * Significant metabolic disorder (e.g. diabetes type II) * Uncontrolled thyroid disease * Recent changes in hypertensive medication (within last 3 months) * Any medical condition that would impact the safety of, or participation in, an exercise program, including: * Significant pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease * Known cardiovascular disease, significant hypertension (\>180/120), or a recent cardiac event (within past 6 months) * Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries * Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
References
Publications (0)
Data not yet available