Clinical trial · Observational
the Value of Transanal Endoscopic ISR
The Value of Transanal Endoscopic Intersphincteric Resection (taE-ISR) in Extreme Anal Preservation in Ultra-low Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Intersphincteric resection (ISR) technique is an alternative for anal preservation in ultra-low rectal cancer. The transanal total mesorectal excision (TaTME) technique might compensate for the deficiencies of ISR in terms of tumor spillage and poor surgical field exposure. Thus, the investigators perform ISR through a transanal endoscopic approach (taE-ISR), seeking to evaluate the value of this innovative technique in anal preservation in ultra-low rectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| transanal endoscopic ISR | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- transanal endoscopic ISR
- interventionNames
- Procedure: transanal endoscopic ISR
- label
- traditional ISR
Primary outcomes (1)
- measure
- anal preservation rate
- timeFrame
- 1 year after sugery
- description
- No conversion to APR and closure was closed within 1 year after surgery
Secondary outcomes (2)
- measure
- incidence of Defecation disorders
- timeFrame
- 6 months after surgery
- description
- A Wexner score \>10 indicated the existence of defecation dysfunction
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age between 18 and 75 years * American Society of Anesthesiologists (ASA) score I to III * A biopsy proven histological diagnosis of rectal carcinoma * preoperative stage as (y) cT1-3N0-2M0 * lower margin of the tumor less than 5cm from the anus * tumor diameter ≤5cm Exclusion Criteria: * Pregnant or lactating women * Synchronous rectal carcinoma * History of colorectal cancer or other malignant tumors * Clinical evidence of metastasis * Emergency procedure
References
Publications (0)
Data not yet available