Clinical trial · Interventional
Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer
Concentrated Ascorbic Acid in DMSO for Treatment of Squamous Cell Carcinoma of the Skin
NCT05932511CI-TRIAL-00069207unknownEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Randomized comparative trial of a 30% solution of ascorbic acid in 95% dimethylsulfoxide applied topically twice a day for 8 weeks vs 5% imiquimod cream in the treatment of biopsy proven squamous cell carcinomas of the skin in otherwise healthy adult patients. Outcome measure was biopsy proven resolution of the carcinoma.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-melanoma Skin Cancer | Skin Carcinoma | ALIAS | 0.90 |
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
| Squamous Cell Cancer | Squamous Cell Carcinoma | ALIAS | 0.90 |
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 30% ascorbic acid in DMSO | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 30% Ascorbic Acid in DMSO
- description
- Topical application twice daily of 300ul 30% (w/v) solution of ascorbic acid in DMSO
- interventionNames
- Drug: 30% ascorbic acid in DMSO
Primary outcomes (1)
- measure
- Lesion Resolution
- timeFrame
- 8 weeks
- description
- Number of lesions tumor free by 2 mm punch biopsy post treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: Presence of biopsy proven squamous cell cancer of the skin - Exclusion Criteria: Previous history of malignancy, diabetes, immunocompromised \-
References
Publications (0)
Data not yet available
No reference posted for this study.