(CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL)

Inclusion Criteria:

* To participate in the study voluntarily and sign the informed consent (ICF), with good compliance and cooperative visits;
* Patients must be ≥ 18 years of age (Based on the date of signing the informed Consent (ICF));
* Pathologically or Histologically confirmed NHL including but not limited to the following subtypes:

  1. Follicular lymphoma (FL);
  2. Chronic lymphocytic leukemia/small lymphocytic lymphoma or Richter syndrome (CLL/SLL or RS);
  3. Marginal zone lymphoma (MZL);
  4. Peripheral T-cell lymphoma (PTCL);
  5. Diffuse large B-cell lymphoma (DLBCL).
* Patients who have received at least one systemic chemotherapy and have relapsed at the end of the treatment or progressed during treatment;
* Must have adequate organ function defined by the following laboratory parameters:

  1. Bone marrow function: Absolute neutrophil count (ANC) ≥ 0.5 × 10\^9/L, Platelet count (PLT) ≥ 25 × 10\^9/L, blood transfusion can be used before medication;
  2. Liver and kidney function: Aspartate transaminase (AST) and alanine aminotransferase (ALT)≤5.0 × ULN;
  3. Estimated creatinine clearance value ≥30 milliliters/minute (as determined by the Cockcroft-Gault method).
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2;
* Patients with infections should be treated first and then considered for enrollment when the infection is under control.

Exclusion Criteria:

* Female subjects who are pregnant or breastfeeding;
* Estimated lifetime is less than 3 months;
* In the investigator's judgment, patients who require but are unable to receive prophylactic treatment for Pneumocystis or herpes simplex virus (HSV) prior to trial drug treatment;
* History or concurrent condition of interstitial lung disease of any severity and/or severely impaired lung function;
* Prior history of drug-induced colitis or drug-induced interstitial pneumonia;
* Known hypersensitivity to Duvelisib or its excipients;
* Administration of medications or foods that are strong inhibitors or inducers of CYP3A beginning 2 weeks prior to the first dose of Duvelisib;
* According to the judgement of the researcher, there are concomitant diseases that seriously endanger the safety of patients or affect the completion of the study.