Clinical trial · Interventional
LISH Trial for the Hepatic Flexure and Proximal Transverse Colon Cancer
Laparoscopic Ileocecal-Sparing Right Hemicolectomy for Cancer of the Hepatic Flexure and Proximal Transverse Colon -- A Prospective, Multicenter Randomized Control Clinical Trial
NCT05923255CI-TRIAL-00101731recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to compare the long-term outcomes of Laparoscopic Ileocecal-Sparing Right Hemicolectomy(LISH) compared to traditional laparoscopic right hemicolectomy(TRH) in the treatment of hepatic flexure colon cancer and proximal transverse colon cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatic Flexure Colon Cancer | — | UNRESOLVED | — |
| Proximal Transverse Colon Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| LISH （Laparoscopic Ileocecal-Sparing Right Hemicolectomy） | Procedure | — | UNRESOLVED |
| TRH（Traditional Laparoscopic Right Hemicolectomy） | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- LISH （Laparoscopic Ileocecal-Sparing Right Hemicolectomy）group
- description
- In LISH group, patients suffering from cancer of the hepatic flexure and proximal transverse colon will be undergoing a novel radical right hemicolectomy technique that allows for the preservation of the ileocecal region.
- interventionNames
- Procedure: LISH （Laparoscopic Ileocecal-Sparing Right Hemicolectomy）
- type
- ACTIVE_COMPARATOR
- label
- TRH （Traditional Right Hemicolectomy）group
- description
- In TRH group, patients suffering from cancer of the hepatic flexure and proximal transverse colon will be undergoing the traditional radical right hemicolectomy.
- interventionNames
- Procedure: TRH（Traditional Laparoscopic Right Hemicolectomy）
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age between 18-75 years old 2. ASA classification ≤III 3. Colon adenocarcinoma confirmed by endoscopy and pathological biopsy 4. Enhanced abdominal CT indicating the primary lesion is located in the hepatic flexure of the colon or proximal transverse colon (proximal 1/3 of the transverse colon) 5. Preoperative clinical staging: TanyNanyM0 6. Patients able to understand the study protocol, willing to participate in the research, and providing written informed consent Exclusion Criteria: 1. Preoperative examination indicates synchronous multiple primary colorectal cancers or other diseases requiring bowel segment resection 2. Preoperative imaging or intraoperative exploration reveals: 1) tumor involving surrounding organs requiring combined organ resection; 2) presence of distant metastasis; 3) inability to perform R0 resection; 4) fused and fixed lymph nodes at the root of the ileocolic vessels 3. Additional radical surgery following Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD) procedures 4. History of any other malignant tumor within the last 5 years or familial adenomatous polyposis, except for cured in situ cervical cancer, basal cell carcinoma, papillary thyroid carcinoma, or skin squamous cell carcinoma 5. Presence of bowel obstruction, bowel perforation, or intestinal bleeding requiring emergency surgery 6. Patients unsuitable for or unable to tolerate laparoscopic surgery 7. Pregnant or lactating women 8. Patients with a history of psychiatric disorders 9. Patients who have received neoadjuvant therapy prior to surgery 10. Patients deemed unsuitable for the study by MDT discussion 11. Patients unable to understand the study's conditions and objectives, and refusing to sign informed consent.
References
Publications (0)
Data not yet available
No reference posted for this study.