Clinical trial · Interventional
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
NCT05921786CI-TRIAL-00079982recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research aims to establish a big database of multiple kinds of brain tissues and prove the relevance of human brain tissue models and hiPSCs-derived organoid models.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Diseases | — | UNRESOLVED | — |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Electrophysiological system | Device | — | UNRESOLVED |
| Multiphoton microscope | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Multiphoton microscopy
- interventionNames
- Device: Multiphoton microscope
- type
- EXPERIMENTAL
- label
- Electrophysiological system
- interventionNames
- Device: Electrophysiological system
Primary outcomes (2)
- measure
- Acquire neuronal structual (image frame) results of different brain regions
- timeFrame
- 3 years
- description
- By interpreting the microscopic images of different brain regions' tissues , an attempt is made to understand the structure of brain disease tissues (via cell morphology, microvessels, etc).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Patients older than the age of 18 with diagnosis of brain disease (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery. Exclusion Criteria: 1. Patients who cannot give consent to participate in the study. 2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow. 3. Patients who only receives biopsy surgery rather than resection surgery. 4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
References
Publications (0)
Data not yet available
No reference posted for this study.