Clinical trial · Interventional
Study to Assess EXS21546 in Combination in Patients With Advanced Solid Tumours
A Phase 1B/2A Study to Assess the Safety, Tolerability, Pharmacokinetic and Anti-tumoral Activity of EXS21546 in Combination With a PD-1 Inhibitor in Patients With Advanced Solid Tumours
NCT05920408CI-TRIAL-00071179terminatedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Emerging data demonstrates challenge for EXS21546 to reach suitable therapeutic index.
Summary
Brief summary (as posted)
A phase 1B/2A study to assess the safety, tolerability, pharmacokinetic and anti-tumoral activity of EXS21546 in combination with a PD-1 inhibitor in patients with advanced solid tumours.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Solid Tumours | Solid Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| EXS21546 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- EXS21546
- description
- EXS21546 Granule in Capsule for oral administration
- interventionNames
- Drug: EXS21546
Primary outcomes (5)
- measure
- Safety of EXS21546 in combination with nivolumab.
- timeFrame
- Through study completion, an average of 6 months
- description
- Incidence of treatment-emergent adverse events (TEAEs) and SAEs characterised by type, incidence, severity (graded by National Cancer Institute \[NCI\] Common Terminology Criteria for Adverse Events \[CTCAE\] v5.0), seriousness, timing and relationship to EXS21546 dosing.
- measure
- Dose-limiting toxicities (DLTs) of EXS21546 in combination with nivolumab.
- timeFrame
- Through dose escalation completion, an average of 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Aged ≥ 18 years at time of informed consent. * Previous histologically confirmed diagnosis of RCC or NSCLC having received previously checkpoint inhibitors as part of a SoC regimen. * Consent to mandatory paired tumour biopsies of at least one tumour site accessible for repeat biopsies. Planned sites for tumour biopsies must not have been previously irradiated and could be a target lesion of \>2 cm diameter according to RECIST v1.1 and must be approved on a case-by-case basis by the Sponsor. * Measurable disease as per RECIST v1.1 and documented by computed tomography (CT) and/or magnetic resonance imaging (MRI). Exclusion Criteria: * Any anti-tumour therapy, including investigational therapies, within 4 weeks prior to the first dose of EXS21546. * Unresolved or unstable serious toxic side-effects of prior chemotherapy or radiotherapy, i.e., ≥ Grade 2 per CTCAE v5.0. * Concurrent other malignancy that could interfere with response evaluation. * Symptomatic central nervous system (CNS) malignancy or metastases. Screening of symptomatic participants without history of CNS metastases is not required. Participants with asymptomatic CNS lesions should have completed standard therapy for their CNS lesions 60 days prior to study enrolment. * History of interstitial lung disease and/or prior immunotherapy-related pneumonitis. * Patients who have had or are scheduled to have major surgery \< 28 days prior to the first dose of study drug.
References
Publications (0)
Data not yet available
No reference posted for this study.