the Effect of Therapeutic Mammoplasty on the Start of Adjuvant Chemotherapy

the purpose of this study was to examine the impact of therapeutic mammoplasty on the delivery of adjuvant chemotherapy

Sex

Female

Minimum age

25 Years

Maximum age

65 Years

Inclusion Criteria:

* Oncoplastic procedures were proposed for patients in whom breast conservative treatment is possible on oncologic grounds but in whose cases a standard resection without reconstruction would result in poor cosmesis with the following criteria:

  1. Female patients with ages ranging from 25 to 65 years
  2. Patients with early surgically treatable breast cancer (Stage I, II and IIIa)
  3. Patients whose management was by surgery followed by adjuvant chemotherapy.
  4. Patients with tumors in any quadrant of the breast
  5. Patients with large/ptotic breasts (especially with brassiere size C, D or DD).
  6. patients underwent therapeutic mammoplasty as primary ttt for breast cancer.

Exclusion Criteria:

* 1\) Patients with a contraindication to breast conservative surgery. 2) Patients with small sized breasts, which are not suitable for reduction (with brassiere size A or B).

  3\) Patients who are not compliant; Non-compliant patients included those demanding mastectomy for fear of local recurrence, patients not consenting to the proposed procedure after adequate counseling, those refusing post-operative adjuvant Radiotherapy, refusal of a reduction mammoplasty of the contralateral breast as a symmetrizing procedure and patients who are not able to consent such as mentally challenged patients.

  4\) patients who have received neoadjuvant chemotherapy. 5) patients underwent conventional breast conservative surgery . 6) patient underwent immediate reconstruction surgery.

• RESULTHarvey J, Henderson J, Patel L, Murphy J, Johnson R. Therapeutic mammaplasty - impact on the delivery of chemotherapy. Int J Surg. 2014;12(5):51-5. doi: 10.1016/j.ijsu.2013.10.013. Epub 2013 Nov 5. PMID 24200754
• RESULTBamford R, Sutton R, McIntosh J. Therapeutic mammoplasty allows for clear surgical margins in large and multifocal tumours without delaying adjuvant therapy. Breast. 2015 Apr;24(2):171-4. doi: 10.1016/j.breast.2015.01.003. Epub 2015 Jan 24. PMID 25623754
• RESULTKhan J, Barrett S, Forte C, Stallard S, Weiler-Mithoff E, Doughty JC, Romics L Jr. Oncoplastic breast conservation does not lead to a delay in the commencement of adjuvant chemotherapy in breast cancer patients. Eur J Surg Oncol. 2013 Aug;39(8):887-91. doi: 10.1016/j.ejso.2013.05.005. Epub 2013 Jun 5. PMID 23746877
• RESULT4. Simpson, Gregory, M. Chandrashekar, and S. Darn.
• RESULTDogan L, Gulcelik MA, Karaman N, Ozaslan C, Reis E. Oncoplastic surgery in surgical treatment of breast cancer: is the timing of adjuvant treatment affected? Clin Breast Cancer. 2013 Jun;13(3):202-5. doi: 10.1016/j.clbc.2012.09.015. Epub 2012 Oct 26. PMID 23103367
• RESULTKlit A, Tvedskov TF, Kroman N, Elberg JJ, Ejlertsen B, Henriksen TF. Oncoplastic breast surgery does not delay the onset of adjuvant chemotherapy: a population-based study. Acta Oncol. 2017 May;56(5):719-723. doi: 10.1080/0284186X.2017.1281437. Epub 2017 Feb 6. PMID 28162018
• RESULTKontos M, Lewis RS, Luchtenborg M, Holmberg L, Hamed H. Does immediate breast reconstruction using free flaps lead to delay in the administration of adjuvant chemotherapy for breast cancer? Eur J Surg Oncol. 2010 Aug;36(8):745-9. doi: 10.1016/j.ejso.2010.06.013. PMID 20605080