Clinical trial · Interventional
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anosmia | — | UNRESOLVED | — |
| Skull Base Neoplasms | Skull Base Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Olfactory training | Other | — | UNRESOLVED |
| Placebo training | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Participants receive placebo olfactory training kits that only contain medium chain triglycerides that lack any discernible odor
- interventionNames
- Other: Placebo training
- type
- EXPERIMENTAL
- label
- Treatment
- description
- Participants receive treatment olfactory training kits that contain essential oils that have scents (lavender, lemon, clove, eucalyptus)
- interventionNames
- Other: Olfactory training
Primary outcomes (1)
- measure
- Change in Olfactory function as assessed by the Sniffin Sticks olfactory testing kit
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * English Speaking * preoperative diagnosis of benign sellar or parasellar skull base pathology Exclusion Criteria: * preoperative diagnosis of malignant sellar or parasellar skull base pathology * history of endoscopic sinus surgery * history of skull base surgery * history of radiation therapy or other local treatments for the management of facial, sinonasal, or cranial pathologies * history of chronic rhinosinusitis * history of neurocognitive disorder * history of intrinsic chemosensory pathology * history of cardiac pacemaker * history of gastrectomy
References
Publications (0)
Data not yet available