Clinical trial · Interventional
Online Adaptive Radiation Therapy for Rectal Cancer
A Prospective Study to Evaluate Online Adaptive Radiotherapy in Rectal Cancer
NCT05911789CI-TRIAL-00068383unknownPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In the present study, the investigators will evaluate the efficacy, toxicities, and of online adaptive radiation therapy (ART) for patients with rectal cancer treated with neoadjuvant chemoradiotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Online adaptive radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Online adaptive radiation therapy
- description
- Patients receive adaptive radiotherapy therapy and concurrent chemotherapy.
- interventionNames
- Radiation: Online adaptive radiation therapy
Primary outcomes (2)
- measure
- Acute toxicities(CTCA
- timeFrame
- 3 months for the start of treatment
- description
- evaluated with Common Terminology Criteria for Adverse Events (CTCAE) 5.0
- measure
- Response rate after surgery
- timeFrame
- 3 monsh after treatment
- description
- Clinical and pathological complete response and partial response rate after chemoradiotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. ≥18 years old; 2. Diagnose with rectal cancer; 3. T3-T4 or N+, and no distant metastasis 4. Neoadjuvant chemoradiotherapy intended; 5. Surgery is expected after neoadjuvant therapy; 6. ECOG score 0-2, expected to lie in the treatment bed for at least half an hour; Exclusion Criteria: 1. With contraindications to rectal MRI; 2. Received surgery, radiotherapy or chemotherapy for rectal cancer; 3. History of pelvic radiotherapy.
References
Publications (0)
Data not yet available
No reference posted for this study.