Clinical trial · Observational
Effectiveness of the Autologous Blood Patch Method in Lung Biopsies
Evaluation of the the Effectiveness of the Autologous Blood Patch Method in Transthoracic Lung Biopsies Using the Coaxial Technique
NCT05904574CI-TRIAL-00067267completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this retrospective study, investigators aimed to evaluate the effectiveness of the autologous blood patch method in percutaneous transthoracic lung biopsies performed with the coaxial technique.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Pneumothorax | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Autologous blood patch | Other | — | UNRESOLVED |
| Percutaneous transthoracic biopsy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- A
- description
- The patients who underwent tru-cut biopsy with the coaxial technique and applied an autologous blood patch.
- interventionNames
- Other: Autologous blood patch
- Other: Percutaneous transthoracic biopsy
- label
- B
- description
- The patients whose true-cut biopsy with coaxial technique was taken and autologous blood patch was not applied.
- interventionNames
- Other: Percutaneous transthoracic biopsy
Primary outcomes (1)
- measure
- Pneumothorax incidence
- timeFrame
- first 24 hours
- description
- Development of pneumothorax after biopsy as a complication
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients older than 18 years * Patients who underwent percutaneous transthoracic tru cut biopsy * Patients undergoing interventional procedures by radiologists with equal experience * Patients who were able to obtain sufficient samples with the applied biopsy (technical success of percutaneous transthoracic biopsy) * Patients whose medical records are fully accessible and whose data are reliable Exclusion Criteria: * Patients whose laboratory bleeding parameters are not suitable for the procedure (platelets\<100000/mm3, INR\>1.5) * Pregnancy * Patients with increased risk of pneumothorax due to other etiologies (bulla, blep, chronic obstructive pulmonary disease, cystic fibrosis) * Patients receiving anticoagulant antiplatelet therapy * Patients with persistent cough * Patients with a history of recent lung travma, pneumothorax, hemoptysis or pulmonary hemorrhage * Patients with severe psychiatric diseases such as psychosis or dementia that limit cooperation with the patient * Patients with anatomic deformity (advanced scoliosis and kyphotic patients. Patients with pectus carinatum and pectus excavatum-like chest deformity) * Patients for whom tru cut biopsy is absolutely and relative contraindicated (suspected hydatid cyst or known vascular lesions such as arteriovenous malformation, pulmonary varicose, severe obstructive pulmonary disease, coagulopathy, moderate to severe pulmonary hypertension, ventilator dependence, unilateral pneumectomy) * Patients allergic to local anesthetic drug used for skin and subcutaneous tissue anesthesia * Patients who do not want to participate
References
Publications (5)
- RESULTSiegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8. PMID 31912902
- RESULTCasal-Mourino A, Valdes L, Barros-Dios JM, Ruano-Ravina A. Lung cancer survival among never smokers. Cancer Lett. 2019 Jun 1;451:142-149. doi: 10.1016/j.canlet.2019.02.047. Epub 2019 Mar 6. PMID 30851418
- RESULTMarshall D, Laberge JM, Firetag B, Miller T, Kerlan RK. The changing face of percutaneous image-guided biopsy: molecular profiling and genomic analysis in current practice. J Vasc Interv Radiol. 2013 Aug;24(8):1094-103. doi: 10.1016/j.jvir.2013.04.027. Epub 2013 Jun 24. PMID 23806383
- RESULTHiraki T, Mimura H, Gobara H, Shibamoto K, Inoue D, Matsui Y, Kanazawa S. Incidence of and risk factors for pneumothorax and chest tube placement after CT fluoroscopy-guided percutaneous lung biopsy: retrospective analysis of the procedures conducted over a 9-year period. AJR Am J Roentgenol. 2010 Mar;194(3):809-14. doi: 10.2214/AJR.09.3224. PMID 20173164
- RESULTHeerink WJ, de Bock GH, de Jonge GJ, Groen HJ, Vliegenthart R, Oudkerk M. Complication rates of CT-guided transthoracic lung biopsy: meta-analysis. Eur Radiol. 2017 Jan;27(1):138-148. doi: 10.1007/s00330-016-4357-8. Epub 2016 Apr 23. PMID 27108299