Clinical trial · Observational
Nevoid Basal Cell Carcinomas in Gorlin Syndrome
Nevoid Basal Cell Carcinomas in Young People With Gorlin Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome. Clinical experience and some case-reports suggest that nevoid basal cell carcinomas have an indolent course with slow growth and that they can sometimes regress. However, no systematic research has previously been performed. Increased knowledge about nevoid basal cell carcinomas and the use of dermatoscopy could be of great clinical value in the follow-up and treatment of individuals with nevoid basal cell carcinoma syndrome.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinoma | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
| Gorlin Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Active surveillance | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Gorlin syndrome
- description
- Children aged six to seventeen years old with Gorlin syndrome and nevoid basal cell carcinomas.
- interventionNames
- Other: Active surveillance
Primary outcomes (2)
- measure
- Nevoid basal cell carcinoma size increase
- timeFrame
- Two years
- description
- Largest diameter (measured in millimeter) of nevoid basal cell carcinomas after two years surveillance compared to at baseline.
- measure
- Dermatoscopy findings
- timeFrame
- Two years
- description
- Dermatoscopy findings of nevoid basal cell carcinomas compared to nevoid basal cell carcinoma size increase.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * The individual has Gorlin syndrome (clinically and/or genetically diagnosed) * The individual is minimum 6 years and maximum 17 years * The individual has at least three skin lesions clinically compatible with nevoid basal cell carcinomas Exclusion Criteria: * The patient has a psychiatric disorder not compatible with completion of the study examinations * The patient has received topical treatment (imiquimod, 5-fluorouracil, photodynamic therapy and/or cryotherapy) of nevoid basal cell carcinomas during the last three months
References
Publications (0)
Data not yet available