Clinical trial · Interventional
Levetiracetam Prophylaxis in Brain Tumor Resection Pilot
Pilot Study: Levetiracetam Prophylaxis Randomized Controlled Trial in Brain Tumor Resection
NCT05897658CI-TRIAL-00081860LeviTaTe Pilotnot yet recruitingPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate feasibility of a double-blind randomized controlled trial for levetiracetam prophylaxis for prevention of seizure in the perioperative phase of brain tumor resection.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Seizures | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Levetiracetam | Drug | — | UNRESOLVED |
| Placebo | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Seizure Prophylaxis (Levetiracetam)
- description
- Levetiracetam 1 g taken orally twice a day for 7 days
- interventionNames
- Drug: Levetiracetam
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Placebo taken orally twice a day for 7 days
- interventionNames
- Other: Placebo
Primary outcomes (1)
- measure
- Recruitment Rate
- timeFrame
- Through study completion, approximately 1 year
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult age 18 years or older * Undergoing craniotomy for a brain tumor * Intra-axial tumor location * Supratentorial tumor location Exclusion Criteria: * Documented seizure history or epilepsy diagnosis * Currently taking an antiepileptic medication * Unable to take levetiracetam (e.g. allergy, inability to swallow) * Inability to obtain consent from participant or substitute decision maker prior to surgery * Renal impairment with eGFR less than 50 * Pregnancy
References
Publications (0)
Data not yet available
No reference posted for this study.