Study and Transformation of Tumor Molecular Features Screening Model of Endometrial Carcinoma Surgical Approach

At present, endometrial carcinoma is one of the three most common malignant tumors in gynecology, and the incidence has been increasing year by year, causing a large health and economic burden to the society. Therefore, researchers regard the hierarchical management and precise diagnosis and treatment of endometrial carcinoma as an important direction for future research. In 2013, the American Cancer Genome Atlas Research Network proposed a molecular typing of endometrial carcinoma. In recent years, international scholars have conducted relevant research on the molecular characteristics of a large number of endometrial carcinomas and immunity, targeted therapy and postoperative adjuvant chemoradiotherapy. However, the molecular characteristics of endometrial carcinoma and the choice of surgical route are still in a relatively lacking state. The previous research of the investigators' group was the first to propose the concept of selecting surgical routes for endometrial carcinoma based on molecular characteristics. Then, on this basis, the investigators' research group plans to carry out a prospective randomized controlled study to further analyze the impact of surgical routes on the short-term safety and long-term prognosis of endometrial carcinoma patients with different molecular characteristics, and transform it into a clinical decision-making technical index system for endometrial carcinoma surgical selection based on molecular characteristics and further promote and apply. The results of this study will make up for the shortcomings in the relevant fields of endometrial carcinoma research in the world to some extent, and become an important aspect of the decision-making system of clinical comprehensive precision diagnosis and treatment of endometrial carcinoma patients.

Sex

Female

Minimum age

40 Years

Maximum age

80 Years

Inclusion Criteria:

* Women aged 40-80 years.
* Preoperative hysteroscopic biopsy pathology is endometrial carcinoma, preoperative imaging evaluation of tumor limited to uterine or extrauterine metastasis limited to pelvic or para-aortic lymph nodes.
* No liver and kidney function abnormalities and bone marrow suppression before surgery.
* ECOG score 0 points.
* Subjects voluntarily joined the study, signed an informed consent form, had good compliance, and cooperated with follow-up.
* Molecular testing has confirmed that the participant does not have high mutational burden characteristics (including POLE mutations, MSI-H, homologous recombinant repair pathway mutations).

Exclusion Criteria:

* Preoperative adjuvant therapy.
* Have contraindications to chemoradiotherapy and cannot receive postoperative adjuvant chemoradiotherapy.
* Previous history of other malignant tumors or other malignant tumors at the same time.
* Laparoscopic surgery transferred to open surgery for special reasons.
* unable or unwilling to comply with the requirements of the study.